Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus
Date
14/10/2017Metadata
Show full item recordAbstract
Deuterium incorporations from [2H1]-(1R,2R) and [2H1]-(1S,2R) glycerols into the fluorine containing antibiotic nucleocidin, in Streptomyces calvus indicate that one deuterium atom is incorporated at the C-5′ site of nucleocidin from each of these isotopomers of glycerol. Two deuteriums become incorporated at C-5′ of nucleocidin after a feeding experiment with [2H5]-glycerol. These observations indicate that there is no obligate oxidation of the pro-R hydroxymethyl group of glycerol as it progresses through the pentose phosphate pathway and becomes incorporated into the fluorinated antibiotic.
Citation
Feng , X , Al Maharik , N , Bartholome , A , Janso , J E , Reilly , U & O'Hagan , D 2017 , ' Incorporation of [ 2 H 1 ]-(1R,2R)- and [ 2 H 1 ]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus ' , Organic & Biomolecular Chemistry , vol. 15 , no. 38 , pp. 8006-8008 . https://doi.org/10.1039/C7OB02163A
Publication
Organic & Biomolecular Chemistry
Status
Peer reviewed
ISSN
1477-0520Type
Journal article
Rights
© 2017 the Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/ 10.1039/C7OB02163A
Description
The authors thank the Chinese Scholarship Council for Ph.D Studentship support (to XF).Collections
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