Files in this item
A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen
Item metadata
dc.contributor.author | Harkness, Gavin J. | |
dc.contributor.author | Clarke, Matthew Lee | |
dc.date.accessioned | 2018-08-31T08:35:20Z | |
dc.date.available | 2018-08-31T08:35:20Z | |
dc.date.issued | 2017-09-01 | |
dc.identifier | 250595953 | |
dc.identifier | 491c2b82-8919-4b89-886d-09e22624b8c7 | |
dc.identifier | 85028616589 | |
dc.identifier | 000408853700026 | |
dc.identifier.citation | Harkness , G J & Clarke , M L 2017 , ' A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen ' , European Journal of Organic Chemistry , vol. 2017 , no. 32 , pp. 4859-4863 . https://doi.org/10.1002/ejoc.201700791 | en |
dc.identifier.issn | 1099-0690 | |
dc.identifier.other | Bibtex: urn:435df28e3f9b0a525fe2f482fc830de9 | |
dc.identifier.other | ORCID: /0000-0002-2444-1244/work/59464627 | |
dc.identifier.uri | https://hdl.handle.net/10023/15914 | |
dc.description | The authors thank the EPSRC for funding for this programme from EP/MC038868/1 and via the DTG. | en |
dc.description.abstract | A highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction. | |
dc.format.extent | 5 | |
dc.format.extent | 1734659 | |
dc.language.iso | eng | |
dc.relation.ispartof | European Journal of Organic Chemistry | en |
dc.subject | Palladium | en |
dc.subject | Asymmetric catalysis | en |
dc.subject | Carbonylation | en |
dc.subject | Hydroesterification | en |
dc.subject | Hydroxycarbonylation | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1002/ejoc.201700791 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-08-31 | |
dc.identifier.grantnumber | EP/M003868/1 | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.