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A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen

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dc.contributor.authorHarkness, Gavin J.
dc.contributor.authorClarke, Matthew Lee
dc.date.accessioned2018-08-31T08:35:20Z
dc.date.available2018-08-31T08:35:20Z
dc.date.issued2017-09-01
dc.identifier.citationHarkness , G J & Clarke , M L 2017 , ' A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen ' , European Journal of Organic Chemistry , vol. 2017 , no. 32 , pp. 4859-4863 . https://doi.org/10.1002/ejoc.201700791en
dc.identifier.issn1099-0690
dc.identifier.otherPURE: 250595953
dc.identifier.otherPURE UUID: 491c2b82-8919-4b89-886d-09e22624b8c7
dc.identifier.otherBibtex: urn:435df28e3f9b0a525fe2f482fc830de9
dc.identifier.otherScopus: 85028616589
dc.identifier.otherORCID: /0000-0002-2444-1244/work/59464627
dc.identifier.otherWOS: 000408853700026
dc.identifier.urihttps://hdl.handle.net/10023/15914
dc.descriptionThe authors thank the EPSRC for funding for this programme from EP/MC038868/1 and via the DTG.en
dc.description.abstractA highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Organic Chemistryen
dc.rights© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/ejoc.201700791en
dc.subjectPalladiumen
dc.subjectAsymmetric catalysisen
dc.subjectCarbonylationen
dc.subjectHydroesterificationen
dc.subjectHydroxycarbonylationen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleA highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofenen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1002/ejoc.201700791
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-08-31
dc.identifier.grantnumberEP/M003868/1en


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