A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen
Abstract
A highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
Citation
Harkness , G J & Clarke , M L 2017 , ' A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen ' , European Journal of Organic Chemistry , vol. 2017 , no. 32 , pp. 4859-4863 . https://doi.org/10.1002/ejoc.201700791
Publication
European Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1099-0690Type
Journal article
Description
The authors thank the EPSRC for funding for this programme from EP/MC038868/1 and via the DTG.Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.