A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen
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A highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
Harkness , G J & Clarke , M L 2017 , ' A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen ' , European Journal of Organic Chemistry , vol. 2017 , no. 32 , pp. 4859-4863 . https://doi.org/10.1002/ejoc.201700791
European Journal of Organic Chemistry
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/ejoc.201700791
DescriptionThe authors thank the EPSRC for funding for this programme from EP/MC038868/1 and via the DTG.
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