Files in this item
Depth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomography
Item metadata
dc.contributor.author | Chen, Mingzhou | |
dc.contributor.author | Mas, Josep | |
dc.contributor.author | Forbes, Lindsey H. | |
dc.contributor.author | Andrews, Melissa R. | |
dc.contributor.author | Dholakia, Kishan | |
dc.date.accessioned | 2018-08-16T23:40:38Z | |
dc.date.available | 2018-08-16T23:40:38Z | |
dc.date.issued | 2018-01 | |
dc.identifier | 249468676 | |
dc.identifier | 0e670ced-0e5b-411f-89d5-6817a411bd83 | |
dc.identifier | 85040777595 | |
dc.identifier | 000425294600029 | |
dc.identifier.citation | Chen , M , Mas , J , Forbes , L H , Andrews , M R & Dholakia , K 2018 , ' Depth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomography ' , Journal of Biophotonics , vol. 11 , no. 1 , e201700129 . https://doi.org/10.1002/jbio.201700129 | en |
dc.identifier.issn | 1864-063X | |
dc.identifier.other | ORCID: /0000-0002-6190-5167/work/47136402 | |
dc.identifier.uri | https://hdl.handle.net/10023/15833 | |
dc.description | Funding: UK Engineering and Physical Sciences Research Council (EPSRC: EP/J01771X/1, EP/M000869/1), the European Union FAMOS project (FP7 ICT, 317744) and the RS MacDonald Charitable Trust for funding. | en |
dc.description.abstract | A major challenge in biophotonics is multimodal imaging to obtain both morphological and molecular information at depth. We demonstrate a hybrid approach integrating optical coherence tomography (OCT) with wavelength modulated spatially offset Raman spectroscopy (WM-SORS). With depth co-localization obtained from the OCT, we can penetrate 1.2mm deep into the strong scattering media (lard) to acquire up to a 14-fold enhancement of a Raman signal from a hidden target (Polystyrene) with a spatial offset. Our approach is also capable of detecting both Raman and OCT signals for pharmaceutical particles embedded in turbid media and revealing the white matter within a brain tissue layer. This depth resolved label-free multimodal approach is a powerful route to analyze complex biomedical samples. | |
dc.format.extent | 7 | |
dc.format.extent | 2467872 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Biophotonics | en |
dc.subject | Raman spectroscopy | en |
dc.subject | Optical coherence tomography | en |
dc.subject | Turbid media | en |
dc.subject | Brain tissue | en |
dc.subject | QC Physics | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | T Technology | en |
dc.subject | NDAS | en |
dc.subject.lcc | QC | en |
dc.subject.lcc | RM | en |
dc.subject.lcc | T | en |
dc.title | Depth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomography | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1002/jbio.201700129 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-08-17 | |
dc.identifier.grantnumber | EP/J01771X/1 | en |
dc.identifier.grantnumber | EP/M000869/1 | en |
dc.identifier.grantnumber | 317744 | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.