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dc.contributor.authorChen, Mingzhou
dc.contributor.authorMas, Josep
dc.contributor.authorForbes, Lindsey H.
dc.contributor.authorAndrews, Melissa R.
dc.contributor.authorDholakia, Kishan
dc.date.accessioned2018-08-16T23:40:38Z
dc.date.available2018-08-16T23:40:38Z
dc.date.issued2018-01
dc.identifier.citationChen , M , Mas , J , Forbes , L H , Andrews , M R & Dholakia , K 2018 , ' Depth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomography ' , Journal of Biophotonics , vol. 11 , no. 1 , e201700129 . https://doi.org/10.1002/jbio.201700129en
dc.identifier.issn1864-063X
dc.identifier.otherPURE: 249468676
dc.identifier.otherPURE UUID: 0e670ced-0e5b-411f-89d5-6817a411bd83
dc.identifier.otherScopus: 85040777595
dc.identifier.otherORCID: /0000-0002-6190-5167/work/47136402
dc.identifier.otherWOS: 000425294600029
dc.identifier.urihttp://hdl.handle.net/10023/15833
dc.descriptionFunding: UK Engineering and Physical Sciences Research Council (EPSRC: EP/J01771X/1, EP/M000869/1), the European Union FAMOS project (FP7 ICT, 317744) and the RS MacDonald Charitable Trust for funding.en
dc.description.abstractA major challenge in biophotonics is multimodal imaging to obtain both morphological and molecular information at depth. We demonstrate a hybrid approach integrating optical coherence tomography (OCT) with wavelength modulated spatially offset Raman spectroscopy (WM-SORS). With depth co-localization obtained from the OCT, we can penetrate 1.2mm deep into the strong scattering media (lard) to acquire up to a 14-fold enhancement of a Raman signal from a hidden target (Polystyrene) with a spatial offset. Our approach is also capable of detecting both Raman and OCT signals for pharmaceutical particles embedded in turbid media and revealing the white matter within a brain tissue layer. This depth resolved label-free multimodal approach is a powerful route to analyze complex biomedical samples.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Biophotonicsen
dc.rights© 2017, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at onlinelibrary.wiley.com / https://doi.org/10.1002/jbio.201700129en
dc.subjectRaman spectroscopyen
dc.subjectOptical coherence tomographyen
dc.subjectTurbid mediaen
dc.subjectBrain tissueen
dc.subjectQC Physicsen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectT Technologyen
dc.subjectNDASen
dc.subject.lccQCen
dc.subject.lccRMen
dc.subject.lccTen
dc.titleDepth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomographyen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1002/jbio.201700129
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-08-17


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