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Depth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomography

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wmrs_v1.pdf (2.353Mb)
Date
01/2018
Author
Chen, Mingzhou
Mas, Josep
Forbes, Lindsey H.
Andrews, Melissa R.
Dholakia, Kishan
Funder
EPSRC
EPSRC
European Commission
Grant ID
EP/J01771X/1
EP/M000869/1
317744
Keywords
Raman spectroscopy
Optical coherence tomography
Turbid media
Brain tissue
QC Physics
RM Therapeutics. Pharmacology
T Technology
NDAS
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Abstract
A major challenge in biophotonics is multimodal imaging to obtain both morphological and molecular information at depth. We demonstrate a hybrid approach integrating optical coherence tomography (OCT) with wavelength modulated spatially offset Raman spectroscopy (WM-SORS). With depth co-localization obtained from the OCT, we can penetrate 1.2mm deep into the strong scattering media (lard) to acquire up to a 14-fold enhancement of a Raman signal from a hidden target (Polystyrene) with a spatial offset. Our approach is also capable of detecting both Raman and OCT signals for pharmaceutical particles embedded in turbid media and revealing the white matter within a brain tissue layer. This depth resolved label-free multimodal approach is a powerful route to analyze complex biomedical samples.
Citation
Chen , M , Mas , J , Forbes , L H , Andrews , M R & Dholakia , K 2018 , ' Depth-resolved multimodal imaging : wavelength modulated spatially offset Raman spectroscopy with optical coherence tomography ' , Journal of Biophotonics , vol. 11 , no. 1 , e201700129 . https://doi.org/10.1002/jbio.201700129
Publication
Journal of Biophotonics
Status
Peer reviewed
DOI
https://doi.org/10.1002/jbio.201700129
ISSN
1864-063X
Type
Journal article
Rights
© 2017, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at onlinelibrary.wiley.com / https://doi.org/10.1002/jbio.201700129
Description
Funding: UK Engineering and Physical Sciences Research Council (EPSRC: EP/J01771X/1, EP/M000869/1), the European Union FAMOS project (FP7 ICT, 317744) and the RS MacDonald Charitable Trust for funding.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/15833

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