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The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias

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Ainge_2018_SR_DiscRatioNOR_CCBY_VoR.pdf (1.261Mb)
Date
01/08/2018
Author
Sivakumaran, Magali H.
MacKenzie, Andrew K.
Callan, Imogen R.
Ainge, James A.
O'Connor, Akira R.
Keywords
BF Psychology
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Abstract
Translational recognition memory research makes frequent use of the Novel Object Recognition (NOR) paradigm in which animals are simultaneously presented with one new and one old object. The preferential exploration of the new as compared to the old object produces a metric, the Discrimination Ratio (DR), assumed to represent recognition memory sensitivity. Human recognition memory studies typically assess performance using signal detection theory derived measures; sensitivity (d′) and bias (c). How DR relates to d′ and c and whether they measure the same underlying cognitive mechanism is, however, unknown. We investigated the correspondence between DR (eye-tracking-determined), d′ and c in a sample of 37 humans. We used dwell times during a visual paired comparison task (analogous to the NOR) to determine DR, and a separate single item recognition task to derive estimates of response sensitivity and bias. DR was found to be significantly positively correlated to sensitivity but not bias. Our findings confirm that DR corresponds to d′, the primary measure of recognition memory sensitivity in humans, and appears not to reflect bias. These findings are the first of their kind to suggest that animal researchers should be confident in interpreting the DR as an analogue of recognition memory sensitivity.
Citation
Sivakumaran , M H , MacKenzie , A K , Callan , I R , Ainge , J A & O'Connor , A R 2018 , ' The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias ' , Scientific Reports , vol. 8 , 11579 . https://doi.org/10.1038/s41598-018-30030-7
Publication
Scientific Reports
Status
Peer reviewed
DOI
https://doi.org/10.1038/s41598-018-30030-7
ISSN
2045-2322
Type
Journal article
Rights
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Description
This work was supported by the Biotechnology and Biological Sciences Research Council UK (BBSRC) under the EastBio doctoral training program [grant number BB/J01446X/1].
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/15749

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