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Synthesis of D-myo-inositol 1,4,5-triphosphate analogues
Item metadata
dc.contributor.advisor | Conway, Stuart J. | |
dc.contributor.author | Bello, Davide | |
dc.coverage.spatial | 233 p. | en |
dc.date.accessioned | 2007-01-25T14:20:19Z | |
dc.date.available | 2007-01-25T14:20:19Z | |
dc.date.issued | 2007 | |
dc.identifier | uk.bl.ethos.551959 | |
dc.identifier.uri | https://hdl.handle.net/10023/156 | |
dc.description.abstract | The cytosolic second messenger D-myo-inositol 1,4,5-trisphosphate (InsP₃), has the ability to mobilise Ca²⁺ from intracellular stores. Ca²⁺ controls a wide range of cellular processes, such as cell division and proliferation, apoptosis, fertilisation, gene transcription and muscle contraction. A number of potent InsP₃ receptor agonists are currently known; however, no selective InsP₃Rs antagonists have been reported to date. Using the X-ray crystal structure of the mouse type 1 InsP₃R, a range of analogues (below) has been designed with the intention of these compounds acting as competitive InsP₃Rs antagonists. The successful syntheses of these compounds are reported herein. | en |
dc.format.extent | 16292964 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | University of St Andrews | |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 2.5 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/ | |
dc.subject.lcc | QP517.C45B4 | |
dc.subject.lcsh | Second messengers (Biochemistry) | en |
dc.subject.lcsh | Organic compounds--Synthesis | en |
dc.title | Synthesis of D-myo-inositol 1,4,5-triphosphate analogues | en |
dc.type | Thesis | en |
dc.type.qualificationlevel | Doctoral | en |
dc.type.qualificationname | PhD Doctor of Philosophy | en |
dc.publisher.institution | The University of St Andrews | en |
dc.publisher.department | Centre for Biomolecular Sciences | en |
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