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dc.contributor.advisorConway, Stuart J.
dc.contributor.authorBello, Davide
dc.coverage.spatial233 p.en
dc.description.abstractThe cytosolic second messenger D-myo-inositol 1,4,5-trisphosphate (InsP₃), has the ability to mobilise Ca²⁺ from intracellular stores. Ca²⁺ controls a wide range of cellular processes, such as cell division and proliferation, apoptosis, fertilisation, gene transcription and muscle contraction. A number of potent InsP₃ receptor agonists are currently known; however, no selective InsP₃Rs antagonists have been reported to date. Using the X-ray crystal structure of the mouse type 1 InsP₃R, a range of analogues (below) has been designed with the intention of these compounds acting as competitive InsP₃Rs antagonists. The successful syntheses of these compounds are reported herein.en
dc.format.extent16292964 bytes
dc.publisherUniversity of St Andrews
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 2.5 Generic
dc.subject.lcshSecond messengers (Biochemistry)en
dc.subject.lcshOrganic compounds--Synthesisen
dc.titleSynthesis of D-myo-inositol 1,4,5-triphosphate analoguesen
dc.type.qualificationnamePhD Doctor of Philosophyen
dc.publisher.institutionThe University of St Andrewsen
dc.publisher.departmentCentre for Biomolecular Sciencesen

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