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Davide Bello - PhD Thesis.pdf15.91 MBAdobe PDFView/Open
Title: Synthesis of D-myo-inositol 1,4,5-triphosphate analogues
Authors: Bello, Davide
Supervisors: Conway, Stuart J.
Issue Date: 2007
Abstract: The cytosolic second messenger D-myo-inositol 1,4,5-trisphosphate (InsP₃), has the ability to mobilise Ca²⁺ from intracellular stores. Ca²⁺ controls a wide range of cellular processes, such as cell division and proliferation, apoptosis, fertilisation, gene transcription and muscle contraction. A number of potent InsP₃ receptor agonists are currently known; however, no selective InsP₃Rs antagonists have been reported to date. Using the X-ray crystal structure of the mouse type 1 InsP₃R, a range of analogues (below) has been designed with the intention of these compounds acting as competitive InsP₃Rs antagonists. The successful syntheses of these compounds are reported herein.
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Type: Thesis
Publisher: University of St Andrews
Appears in Collections:Chemistry Theses

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