Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorClark, Joshua
dc.contributor.authorO'Hagan, David
dc.date.accessioned2018-07-04T23:34:27Z
dc.date.available2018-07-04T23:34:27Z
dc.date.issued2017-11
dc.identifier.citationClark , J & O'Hagan , D 2017 , ' Strategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET) ' , Journal of Fluorine Chemistry , vol. 203 , pp. 31-46 . https://doi.org/10.1016/j.jfluchem.2017.08.001en
dc.identifier.issn0022-1139
dc.identifier.otherPURE: 250673993
dc.identifier.otherPURE UUID: 8332f9c5-0f10-40ae-b456-3f82e0d87361
dc.identifier.otherRIS: urn:CEF62C6666A10A63289C51744EFCB300
dc.identifier.otherScopus: 85028083015
dc.identifier.otherWOS: 000418727100003
dc.identifier.urihttp://hdl.handle.net/10023/14944
dc.description.abstractThe use of fluorine-18 as a radionuclide for positron emission tomography (PET) has become increasingly popular over the last two decades and cancer and neurology clinical centres worldwide are increasingly establishing competence in this modality for diagnostic imaging. Progress has been particularly impressive for small molecule pharmaceutical candidates and low molecular weight affinity peptides, where clearance rates of the peptides in the body are compatible with the half-life of fluorine-18 (t1/2 = 110 min). However high molecular weight proteins present challenges as they circulate and clear much more slowly. This review focuses on the methods used to radiolabel antibodies and their derivatives with fluorine-18 as tracers for PET. The very high specificity of these biomolecules for disease indicators at the molecular level makes labelling them attractive, however antibodies can circulate for days within the blood, with slow clearance times due to their high molecular weights, and this is inconsistent with the relatively short half-life of fluorine-18. Thus, lower molecular weight fragments of antibodies present more realistic targets for labelling. This review describes the approaches and protocols which have been successfully used to radiolabel antibodies and particularly antibody fragments with fluorine-18, and highlights this challenging aspect of fluorine-18 labelling for PET imaging.
dc.language.isoeng
dc.relation.ispartofJournal of Fluorine Chemistryen
dc.rights© 2017 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jfluchem.2017.08.001en
dc.subjectFluorine-18en
dc.subjectPositron emission tomographyen
dc.subjectAntibodyen
dc.subjectAntibody fragmenten
dc.subjectBioconjugationen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleStrategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET)en
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1016/j.jfluchem.2017.08.001
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-07-05


This item appears in the following Collection(s)

Show simple item record