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Strategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET)

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Clark_2017_JFC_PET_AAM.pdf (973.1Kb)
Date
11/2017
Author
Clark, Joshua
O'Hagan, David
Keywords
Fluorine-18
Positron emission tomography
Antibody
Antibody fragment
Bioconjugation
QD Chemistry
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Abstract
The use of fluorine-18 as a radionuclide for positron emission tomography (PET) has become increasingly popular over the last two decades and cancer and neurology clinical centres worldwide are increasingly establishing competence in this modality for diagnostic imaging. Progress has been particularly impressive for small molecule pharmaceutical candidates and low molecular weight affinity peptides, where clearance rates of the peptides in the body are compatible with the half-life of fluorine-18 (t1/2 = 110 min). However high molecular weight proteins present challenges as they circulate and clear much more slowly. This review focuses on the methods used to radiolabel antibodies and their derivatives with fluorine-18 as tracers for PET. The very high specificity of these biomolecules for disease indicators at the molecular level makes labelling them attractive, however antibodies can circulate for days within the blood, with slow clearance times due to their high molecular weights, and this is inconsistent with the relatively short half-life of fluorine-18. Thus, lower molecular weight fragments of antibodies present more realistic targets for labelling. This review describes the approaches and protocols which have been successfully used to radiolabel antibodies and particularly antibody fragments with fluorine-18, and highlights this challenging aspect of fluorine-18 labelling for PET imaging.
Citation
Clark , J & O'Hagan , D 2017 , ' Strategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET) ' , Journal of Fluorine Chemistry , vol. 203 , pp. 31-46 . https://doi.org/10.1016/j.jfluchem.2017.08.001
Publication
Journal of Fluorine Chemistry
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.jfluchem.2017.08.001
ISSN
0022-1139
Type
Journal item
Rights
© 2017 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jfluchem.2017.08.001
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URI
http://hdl.handle.net/10023/14944

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