Show simple item record

Files in this item


Item metadata

dc.contributor.authorSteward, Karen F.
dc.contributor.authorRobinson, Carl
dc.contributor.authorHolden, Matthew T. G.
dc.contributor.authorHarris, Simon R.
dc.contributor.authorRos, Ana Fernández
dc.contributor.authorPérez, Gema Chacón
dc.contributor.authorBaselga, Rafael
dc.contributor.authorWaller, Andrew S.
dc.identifier.citationSteward , K F , Robinson , C , Holden , M T G , Harris , S R , Ros , A F , Pérez , G C , Baselga , R & Waller , A S 2017 , ' Diversity of Streptococcus equi subsp. zooepidemicus strains isolated from the Spanish sheep and goat population and the identification, function and prevalence of a novel arbutin utilisation system ' , Veterinary Microbiology , vol. 207 , pp. 231-238 .
dc.identifier.otherPURE: 250666600
dc.identifier.otherPURE UUID: 5ad237ff-df2d-4eb4-b895-f5162726199f
dc.identifier.otherPubMed: 28757029
dc.identifier.otherScopus: 85021861215
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196425
dc.descriptionThis work was supported by the Animal Health Trust.en
dc.description.abstractThe zoonotic bacterium Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is a diverse, opportunistic pathogen that can cause mastitis in dairy sheep and goats. We used multilocus sequence typing (MLST) to define the genetic diversity of 60 isolates of S. zooepidemicus, which were recovered from sheep and goats in Spain between 2003 and 2010. We identify a novel clonal complex based on sequence type (ST), ST-236, which accounted for 39 of the 60 isolates. A representative ST-236 strain, S. zooepidemicus strain C7 (SzC7), was sequenced and interrogated for the presence of novel nutritional uptake or utilisation systems, the acquisition of which have previously been shown to be important for environmental adaptation in other streptococcal pathogens. A novel phosphoenolpyruvate sugar phosphotransferase system (PTS), which enabled the utilisation of arbutin, was identified. Functionality of the PTS was confirmed following deletion of the PTS from SzC7. Arbutin is found in multiple animal foodstuffs and we propose that the ability to utilise arbutin may have conferred a selective advantage to strains infecting animals, the diet of which contains this sugar.
dc.relation.ispartofVeterinary Microbiologyen
dc.rights© 2017, Elsevier BV. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at /
dc.subjectStreptococcus zooepedemicusen
dc.subjectArbutin utilisationen
dc.subjectPTS system acquisitionen
dc.subjectQR Microbiologyen
dc.subjectSF Animal cultureen
dc.titleDiversity of Streptococcus equi subsp. zooepidemicus strains isolated from the Spanish sheep and goat population and the identification, function and prevalence of a novel arbutin utilisation systemen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record