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dc.contributor.authorWeir-McCall, Jonathan R.
dc.contributor.authorLambert, Matthew
dc.contributor.authorGandy, Stephen J.
dc.contributor.authorBelch, Jill J. F.
dc.contributor.authorCavin, Ian
dc.contributor.authorHenderson, Shelley A.
dc.contributor.authorLittleford, Roberta
dc.contributor.authorMacfarlane, Jennifer A.
dc.contributor.authorMatthew, Shona Z.
dc.contributor.authorNicholas, R. Stephen
dc.contributor.authorStruthers, Allan D.
dc.contributor.authorSullivan, Frank
dc.contributor.authorWhite, Richard D.
dc.contributor.authorHouston, J. Graeme
dc.date.accessioned2018-04-23T11:30:05Z
dc.date.available2018-04-23T11:30:05Z
dc.date.issued2018-01-30
dc.identifier252883058
dc.identifierbf0641e8-11bb-44a4-80d4-17c297738a9f
dc.identifier000423591400001
dc.identifier85041341829
dc.identifier.citationWeir-McCall , J R , Lambert , M , Gandy , S J , Belch , J J F , Cavin , I , Henderson , S A , Littleford , R , Macfarlane , J A , Matthew , S Z , Nicholas , R S , Struthers , A D , Sullivan , F , White , R D & Houston , J G 2018 , ' Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis : a TASCFORCE study ' , Journal of Cardiovascular Magnetic Resonance , vol. 20 , 7 . https://doi.org/10.1186/s12968-018-0428-0en
dc.identifier.issn1097-6647
dc.identifier.otherORCID: /0000-0002-6623-4964/work/43873426
dc.identifier.urihttps://hdl.handle.net/10023/13184
dc.descriptionThe present study was funded by the Souter Charitable Foundation and the Chest, Heart and Stroke Scotland Charity. The statistician was funded by TENOVUS, Tayside. JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship.en
dc.description.abstractBackground: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk. Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a <20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR). Results: One thousand five hundred fifteen (38% male, 53.8 +/- 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = -0.001 (-0.004-0.002),p = 0.62) and females (B = 0.000(95% CI -0.002-0.002), p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95% CI -0.16-0.091), p <0.001 in males; B = - 0.12(95% CI -0.15-0.086), p <0.001 in females). Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.
dc.format.extent11
dc.format.extent1601685
dc.language.isoeng
dc.relation.ispartofJournal of Cardiovascular Magnetic Resonanceen
dc.subjectArterial complainceen
dc.subjectArteriosclerosisen
dc.subjectAtherosclerosisen
dc.subjectLeft ventricleen
dc.subjectCardiovascular risken
dc.subjectRC Internal medicineen
dc.subjectRZ Other systems of medicineen
dc.subjectQC Physicsen
dc.subjectE-NDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRCen
dc.subject.lccRZen
dc.subject.lccQCen
dc.titleSystemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis : a TASCFORCE studyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.identifier.doi10.1186/s12968-018-0428-0
dc.description.statusPeer revieweden


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