St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis : a TASCFORCE study

Thumbnail
View/Open
Weir_McCall_2018_JCMR_systemicarteriosclerosis_CC.pdf (1.527Mb)
Date
30/01/2018
Author
Weir-McCall, Jonathan R.
Lambert, Matthew
Gandy, Stephen J.
Belch, Jill J. F.
Cavin, Ian
Henderson, Shelley A.
Littleford, Roberta
Macfarlane, Jennifer A.
Matthew, Shona Z.
Nicholas, R. Stephen
Struthers, Allan D.
Sullivan, Frank
White, Richard D.
Houston, J. Graeme
Keywords
Arterial complaince
Arteriosclerosis
Atherosclerosis
Left ventricle
Cardiovascular risk
RC Internal medicine
RZ Other systems of medicine
QC Physics
E-NDAS
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk. Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a <20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR). Results: One thousand five hundred fifteen (38% male, 53.8 +/- 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = -0.001 (-0.004-0.002),p = 0.62) and females (B = 0.000(95% CI -0.002-0.002), p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95% CI -0.16-0.091), p <0.001 in males; B = - 0.12(95% CI -0.15-0.086), p <0.001 in females). Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.
Citation
Weir-McCall , J R , Lambert , M , Gandy , S J , Belch , J J F , Cavin , I , Henderson , S A , Littleford , R , Macfarlane , J A , Matthew , S Z , Nicholas , R S , Struthers , A D , Sullivan , F , White , R D & Houston , J G 2018 , ' Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis : a TASCFORCE study ' , Journal of Cardiovascular Magnetic Resonance , vol. 20 , 7 . https://doi.org/10.1186/s12968-018-0428-0
Publication
Journal of Cardiovascular Magnetic Resonance
Status
Peer reviewed
DOI
https://doi.org/10.1186/s12968-018-0428-0
ISSN
1097-6647
Type
Journal article
Rights
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Description
The present study was funded by the Souter Charitable Foundation and the Chest, Heart and Stroke Scotland Charity. The statistician was funded by TENOVUS, Tayside. JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/13184

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter