A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Widegren, Magnus B.; Harkness, Gavin J.; Slawin, Alexandra M. Z.; Cordes, David B.; Clarke, Matthew L.

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dc.contributor.author	Widegren, Magnus B.
dc.contributor.author	Harkness, Gavin J.
dc.contributor.author	Slawin, Alexandra M. Z.
dc.contributor.author	Cordes, David B.
dc.contributor.author	Clarke, Matthew L.
dc.date.accessioned	2018-04-20T23:33:04Z
dc.date.available	2018-04-20T23:33:04Z
dc.date.issued	2017-05-15
dc.identifier.citation	Widegren , M B , Harkness , G J , Slawin , A M Z , Cordes , D B & Clarke , M L 2017 , ' A highly active manganese catalyst for enantioselective ketone and ester hydrogenation ' , Angewandte Chemie , vol. 129 , no. 21 , pp. 5919-5922 . https://doi.org/10.1002/ange.201702406	en
dc.identifier.issn	0044-8249
dc.identifier.other	PURE: 249586929
dc.identifier.other	PURE UUID: ca65ee1f-1438-41a7-a6d9-c4285e0a80c9
dc.identifier.other	ORCID: /0000-0002-5366-9168/work/32087327
dc.identifier.other	ORCID: /0000-0002-9527-6418/work/56861910
dc.identifier.other	ORCID: /0000-0002-2444-1244/work/59464632
dc.identifier.uri	http://hdl.handle.net/10023/13175
dc.description	We thank the EPSRC for DTG funding for M.B.W. and G.J.H. and for the use of the National Mass Spectrometry Service. The technical support staff at St Andrews are also gratefully acknowledged. The research data underpinning this paper can be accessed at: https://doi.org/10.17630/91ab7775-867c-4b21-97c7-7c9117269ada.	en
dc.description.abstract	A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 oC.
dc.format.extent	4
dc.language.iso	eng
dc.relation.ispartof	Angewandte Chemie	en
dc.rights	© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1002/anie.201702406	en
dc.subject	Manganese	en
dc.subject	Reduction	en
dc.subject	Ester hydrogenation	en
dc.subject	Ferrocene	en
dc.subject	Enantioselective catalysis	en
dc.subject	QD Chemistry	en
dc.subject	TP Chemical technology	en
dc.subject	DAS	en
dc.subject.lcc	QD	en
dc.subject.lcc	TP	en
dc.title	A highly active manganese catalyst for enantioselective ketone and ester hydrogenation	en
dc.type	Journal article	en
dc.description.version	Postprint	en
dc.contributor.institution	University of St Andrews.School of Chemistry	en
dc.contributor.institution	University of St Andrews.EaSTCHEM	en
dc.identifier.doi	https://doi.org/10.1002/ange.201702406
dc.description.status	Peer reviewed	en
dc.date.embargoedUntil	2018-04-20
dc.identifier.url	http://onlinelibrary.wiley.com/doi/10.1002/ange.201702406/full#footer-support-info	en

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