A highly active manganese catalyst for enantioselective ketone and ester hydrogenation
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A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 oC.
Widegren , M B , Harkness , G J , Slawin , A M Z , Cordes , D B & Clarke , M L 2017 , ' A highly active manganese catalyst for enantioselective ketone and ester hydrogenation ' Angewandte Chemie , vol. 129 , no. 21 , pp. 5919-5922 . https://doi.org/10.1002/ange.201702406
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1002/anie.201702406
DescriptionWe thank the EPSRC for DTG funding for M.B.W. and G.J.H. and for the use of the National Mass Spectrometry Service. The technical support staff at St Andrews are also gratefully acknowledged. The research data underpinning this paper can be accessed at: https://doi.org/10.17630/91ab7775-867c-4b21-97c7-7c9117269ada.
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