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dc.contributor.authorSloan, Derek J
dc.contributor.authorNicolson, Andrew
dc.contributor.authorMiller, Alastair RO
dc.contributor.authorBeeching, Nick J
dc.contributor.authorBeadsworth, Mike BJ
dc.identifier.citationSloan , D J , Nicolson , A , Miller , A RO , Beeching , N J & Beadsworth , M BJ 2008 , ' Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy : a case report ' , Journal of Medical Case Reports , vol. 2 , 370 .
dc.identifier.otherPURE: 241962617
dc.identifier.otherPURE UUID: 02e6528a-495a-4827-a4d8-632d7841c1fa
dc.identifier.otherBibtex: urn:e0d3174b17ad0efaec42a73d5b368495
dc.identifier.otherScopus: 59049103227
dc.identifier.otherORCID: /0000-0002-7888-5449/work/60631037
dc.description.abstractIntroduction: Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneuropathy has occasionally been reported in acute Immunodeficiency Virus infection but little data exists on frequency, management and outcome. Case presentation:  We describe an episode of Guillain-Barré syndrome presenting as acute inflammatory demyelinating polyneuropathy in a 30-year-old man testing positive for Immunodeficiency Virus, probably during acute seroconversion. Clinical suspicion was confirmed by cerebrospinal fluid analysis and nerve conduction studies. Rapid clinical deterioration prompted intravenous immunoglobulin therapy and early commencement of highly active anti-retroviral therapy. All symptoms resolved within nine weeks. Conclusion:  Unusual neurological presentations in previously fit patients are an appropriate indication for Immunodeficiency-Virus testing. Highly active anti-retroviral therapy with adequate penetration of the central nervous system should be considered as an early intervention, alongside conventional therapies such as intravenous immunoglobulin.
dc.relation.ispartofJournal of Medical Case Reportsen
dc.rights© Sloan et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectHuman immunodeficiency virusen
dc.subjectHuman immunodeficiency virus testingen
dc.subjectIntravenous immunoglobulin therapyen
dc.subjectAcute inflammatory demyelinating polyneuropathyen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleHuman immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy : a case reporten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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