A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications
Abstract
Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.
Citation
Russell , S E , González Carballo , J M , Orellana-Tavra , C , Fairen-Jimenez , D & Morris , R E 2017 , ' A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications ' , Dalton Transactions , vol. 46 , no. 12 , pp. 3915-3920 . https://doi.org/10.1039/C7DT00195A
Publication
Dalton Transactions
Status
Peer reviewed
ISSN
1477-9226Type
Journal article
Description
The authors would like to thank the Engineering and Physical Sciences Research Council, University of St Andrews, and CRITICAT Centre for Doctoral Training for financial support [Ph.D. studentship to SR; Grant code: EP/L016419/1]. C. A. O. thanks Becas Chile and the Cambridge Trust for funding. D. F.-J. thanks the Royal Society (UK) for funding through a University Research Fellowship. Thanks also go to Chevron for the sample of H-SSZ-13.Collections
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