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dc.contributor.authorWilson, Kirsty
dc.contributor.authorKennedy, Alan
dc.contributor.authorMurray, Jane
dc.contributor.authorGreatex, Ben
dc.contributor.authorJamieson, Craig
dc.contributor.authorWatson, Allan
dc.date.accessioned2018-02-07T15:30:08Z
dc.date.available2018-02-07T15:30:08Z
dc.date.issued2016-09-08
dc.identifier.citationWilson , K , Kennedy , A , Murray , J , Greatex , B , Jamieson , C & Watson , A 2016 , ' Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation ' Beilstein Journal of Organic Chemistry , vol. 12 , pp. 2005-2011 . DOI: 10.3762/bjoc.12.187en
dc.identifier.issn1860-5397
dc.identifier.otherPURE: 252198665
dc.identifier.otherPURE UUID: c2155a44-1bb0-4f49-8664-56cadccb53e2
dc.identifier.otherRIS: urn:E94AD5EE22332517878537149D605300
dc.identifier.otherScopus: 84988697854
dc.identifier.urihttp://hdl.handle.net/10023/12688
dc.descriptionWe thank the University of Strathclyde for a PhD studentship (KLW), Sigma-Aldrich for financial and material support, Circa for Cyrene, and the EPSRC UK National Mass Spectrometry Facility at Swansea University for analyses.en
dc.description.abstractPd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (CyreneTM) in Sonogashira crosscoupling and Cacchi-type annulations.en
dc.format.extent7en
dc.language.isoeng
dc.relation.ispartofBeilstein Journal of Organic Chemistryen
dc.rights© 2016 Wilson et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectCacchi annulationen
dc.subjectCross-couplingen
dc.subjectHeterocyclesen
dc.subjectSonogashiraen
dc.subjectSustainable solventen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleScope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doihttps://doi.org/10.3762/bjoc.12.187
dc.description.statusPeer revieweden


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