Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
Abstract
Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (CyreneTM) in Sonogashira crosscoupling and Cacchi-type annulations.
Citation
Wilson , K , Kennedy , A , Murray , J , Greatex , B , Jamieson , C & Watson , A 2016 , ' Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation ' , Beilstein Journal of Organic Chemistry , vol. 12 , pp. 2005-2011 . https://doi.org/10.3762/bjoc.12.187
Publication
Beilstein Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1860-5397Type
Journal article
Rights
© 2016 Wilson et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description
We thank the University of Strathclyde for a PhD studentship (KLW), Sigma-Aldrich for financial and material support, Circa for Cyrene, and the EPSRC UK National Mass Spectrometry Facility at Swansea University for analyses.Collections
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