Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
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Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (CyreneTM) in Sonogashira crosscoupling and Cacchi-type annulations.
Wilson , K , Kennedy , A , Murray , J , Greatex , B , Jamieson , C & Watson , A 2016 , ' Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation ' Beilstein Journal of Organic Chemistry , vol 12 , pp. 2005-2011 . DOI: 10.3762/bjoc.12.187
Beilstein Journal of Organic Chemistry
© 2016 Wilson et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We thank the University of Strathclyde for a PhD studentship (KLW), Sigma-Aldrich for financial and material support, Circa for Cyrene, and the EPSRC UK National Mass Spectrometry Facility at Swansea University for analyses.
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