Aggregation and travelling wave dynamics in a two-population model of cancer cell growth and invasion
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Cells adhere to each other and to the extracellular matrix (ECM) through protein molecules on the surface of the cells. The breaking and forming of adhesive bonds, a process critical in cancer invasion and metas- tasis, can be influenced by the mutation of cancer cells. In this paper, we develop a nonlocal mathematical model describing cancer cell invasion and movement as a result of integrin-controlled cell-cell adhesion and cell-matrix adhesion, for two cancer cell populations with different levels of mutation. The partial differential equations for cell dynamics are coupled with ordinary differential equations describing the extracellular matrix (ECM) degradation and the production and decay of integrins. We use this model to investigate the role of cancer mutation on the possibility of cancer clonal competition with alternating dominance, or even competitive exclusion (phenomena observed experimentally). We discuss different possible cell aggregation patterns, as well as travelling wave patterns. In regard to the travelling waves, we investigate the effect of cancer mutation rate on the speed of cancer invasion.
Bitsouni , V , Trucu , D , Chaplain , M A J & Eftimie , R 2018 , ' Aggregation and travelling wave dynamics in a two-population model of cancer cell growth and invasion ' Mathematical Medicine and Biology , vol Advance articles . DOI: 10.1093/imammb/dqx019
Mathematical Medicine and Biology
© The Author(s) 2018. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Funding: Engineering and Physical Sciences Research Council (UK) grant numbers EP/L504932/1 (VB), EP/K033689/1 (RE).
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