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dc.contributor.authorBertrand, Stephanie
dc.contributor.authorLe Petillon, Yann
dc.contributor.authorSomorjai, Ildiko Maureen Lara
dc.contributor.authorEscriva, Hector
dc.identifier.citationBertrand , S , Le Petillon , Y , Somorjai , I M L & Escriva , H 2017 , ' Developmental cell-cell communication pathways in the cephalochordate amphioxus: actors and functions ' , International Journal of Developmental Biology , vol. 61 , no. 10/11/12 , pp. 697-722 .
dc.descriptionThe laboratory of H.E. was supported by the CNRS and the ANR16-CE12-0008-01 and S.B. by the Institut Universitaire de France. The laboratory of I.M.L.S. is currently supported by Wellcome Trust ISSF grant 204821/Z/16/Zen
dc.description.abstractDuring embryonic development, cells of metazoan embryos need to communicate in order to construct the correct bodyplan. To do so, they use several signals that usually act through interactions between ligands and receptors. Interestingly, only a few pathways are known to be fundamental during animal development, and they are usually found in all the major metazoan clades, raising the following question: how have evolution of the actors and of the functions of these pathways participated in the appearance of the current diversity of animal morphologies? The chordate lineage comprises vertebrates, their sister group the urochordates, and the cephalochordates (i.e. amphioxus). Urochordates are quite derived relative to the chordate ancestor, whereas cephalochordates and vertebrates share many morphological traits. Thus, comparing embryonic development between vertebrates and cephalochordates should give us some insight into the ancestral characters present in chordates and into the morphological evolution in this clade. However, while much is known about the function of different signalling pathways in vertebrates, data are still scarce in the literature for cephalochordates. In this review, we summarize the current state of the field concerning the expression of actors and the function of the major cell-cell communication pathways, including Hedgehog (Hh), Notch, Nuclear Receptor (NR), Receptor Tyrosine Kinase (RTK), Transforming Growth Factor-β (TGF-β) and Wingless/Int (Wnt), in amphioxus.
dc.relation.ispartofInternational Journal of Developmental Biologyen
dc.subjectSignalling pathwaysen
dc.subjectQH301 Biologyen
dc.titleDevelopmental cell-cell communication pathways in the cephalochordate amphioxus: actors and functionsen
dc.typeJournal itemen
dc.contributor.sponsorThe Wellcome Trusten
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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