Show simple item record

Files in this item

Item metadata

dc.contributor.authorBertrand, Stephanie
dc.contributor.authorLe Petillon, Yann
dc.contributor.authorSomorjai, Ildiko Maureen Lara
dc.contributor.authorEscriva, Hector
dc.date.accessioned2017-12-22T10:30:07Z
dc.date.available2017-12-22T10:30:07Z
dc.date.issued2017-12-21
dc.identifier.citationBertrand , S , Le Petillon , Y , Somorjai , I M L & Escriva , H 2017 , ' Developmental cell-cell communication pathways in the cephalochordate amphioxus: actors and functions ' International Journal of Developmental Biology , vol 61 , no. 10/11/12 , pp. 697-722 . DOI: 10.1387/ijdb.170202sben
dc.identifier.issn0214-6282
dc.identifier.otherPURE: 250513376
dc.identifier.otherPURE UUID: 0d01f7d0-c2f1-4540-8677-606cb56796d5
dc.identifier.otherScopus: 85039717325
dc.identifier.urihttp://hdl.handle.net/10023/12379
dc.identifier.urihttp://www.ijdb.ehu.es/web/paper/170202sb/developmental-cell-cell-communication-pathways-in-the-cephalochordate-amphioxus-actors-and-functionsen
dc.descriptionThe laboratory of H.E. was supported by the CNRS and the ANR16-CE12-0008-01 and S.B. by the Institut Universitaire de France. The laboratory of I.M.L.S. is currently supported by Wellcome Trust ISSF grant 204821/Z/16/Zen
dc.description.abstractDuring embryonic development, cells of metazoan embryos need to communicate in order to construct the correct bodyplan. To do so, they use several signals that usually act through interactions between ligands and receptors. Interestingly, only a few pathways are known to be fundamental during animal development, and they are usually found in all the major metazoan clades, raising the following question: how have evolution of the actors and of the functions of these pathways participated in the appearance of the current diversity of animal morphologies? The chordate lineage comprises vertebrates, their sister group the urochordates, and the cephalochordates (i.e. amphioxus). Urochordates are quite derived relative to the chordate ancestor, whereas cephalochordates and vertebrates share many morphological traits. Thus, comparing embryonic development between vertebrates and cephalochordates should give us some insight into the ancestral characters present in chordates and into the morphological evolution in this clade. However, while much is known about the function of different signalling pathways in vertebrates, data are still scarce in the literature for cephalochordates. In this review, we summarize the current state of the field concerning the expression of actors and the function of the major cell-cell communication pathways, including Hedgehog (Hh), Notch, Nuclear Receptor (NR), Receptor Tyrosine Kinase (RTK), Transforming Growth Factor-β (TGF-β) and Wingless/Int (Wnt), in amphioxus.en
dc.format.extent26en
dc.language.isoeng
dc.relation.ispartofInternational Journal of Developmental Biologyen
dc.rights© 2017 UPV/EHU Press (Bilbao, Spain) / the Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/), which permits you to Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material for any purpose, even commercially), providing you give appropriate credit, provide a link to the license, and indicate if changes were made.en
dc.subjectChordatesen
dc.subjectEvolutionen
dc.subjectDevelopmenten
dc.subjectSignalling pathwaysen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleDevelopmental cell-cell communication pathways in the cephalochordate amphioxus: actors and functionsen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1387/ijdb.170202sb
dc.description.statusPeer revieweden


The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record