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Developmental cell-cell communication pathways in the cephalochordate amphioxus: actors and functions

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Somorjai_2017_IJDB_Cell_Cell_CCBY_VoR.pdf (5.271Mb)
Date
21/12/2017
Author
Bertrand, Stephanie
Le Petillon, Yann
Somorjai, Ildiko Maureen Lara
Escriva, Hector
Keywords
Chordates
Evolution
Development
Signalling pathways
QH301 Biology
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Abstract
During embryonic development, cells of metazoan embryos need to communicate in order to construct the correct bodyplan. To do so, they use several signals that usually act through interactions between ligands and receptors. Interestingly, only a few pathways are known to be fundamental during animal development, and they are usually found in all the major metazoan clades, raising the following question: how have evolution of the actors and of the functions of these pathways participated in the appearance of the current diversity of animal morphologies? The chordate lineage comprises vertebrates, their sister group the urochordates, and the cephalochordates (i.e. amphioxus). Urochordates are quite derived relative to the chordate ancestor, whereas cephalochordates and vertebrates share many morphological traits. Thus, comparing embryonic development between vertebrates and cephalochordates should give us some insight into the ancestral characters present in chordates and into the morphological evolution in this clade. However, while much is known about the function of different signalling pathways in vertebrates, data are still scarce in the literature for cephalochordates. In this review, we summarize the current state of the field concerning the expression of actors and the function of the major cell-cell communication pathways, including Hedgehog (Hh), Notch, Nuclear Receptor (NR), Receptor Tyrosine Kinase (RTK), Transforming Growth Factor-β (TGF-β) and Wingless/Int (Wnt), in amphioxus.
Citation
Bertrand , S , Le Petillon , Y , Somorjai , I M L & Escriva , H 2017 , ' Developmental cell-cell communication pathways in the cephalochordate amphioxus: actors and functions ' , International Journal of Developmental Biology , vol. 61 , no. 10/11/12 , pp. 697-722 . https://doi.org/10.1387/ijdb.170202sb
Publication
International Journal of Developmental Biology
Status
Peer reviewed
DOI
https://doi.org/10.1387/ijdb.170202sb
ISSN
0214-6282
Type
Journal item
Rights
© 2017 UPV/EHU Press (Bilbao, Spain) / the Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/), which permits you to Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material for any purpose, even commercially), providing you give appropriate credit, provide a link to the license, and indicate if changes were made.
Description
The laboratory of H.E. was supported by the CNRS and the ANR16-CE12-0008-01 and S.B. by the Institut Universitaire de France. The laboratory of I.M.L.S. is currently supported by Wellcome Trust ISSF grant 204821/Z/16/Z
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URL
http://www.ijdb.ehu.es/web/paper/170202sb/developmental-cell-cell-communication-pathways-in-the-cephalochordate-amphioxus-actors-and-functions
URI
http://hdl.handle.net/10023/12379

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