Files in this item
A biocatalytic approach towards the stereoselective synthesis of protected inositols
Item metadata
dc.contributor.author | Sayer, Lloyd H. | |
dc.contributor.author | Florence, Gordon J. | |
dc.contributor.author | Smith, Terry | |
dc.date.accessioned | 2017-12-13T00:32:00Z | |
dc.date.available | 2017-12-13T00:32:00Z | |
dc.date.issued | 2017-02-01 | |
dc.identifier | 248184898 | |
dc.identifier | a3afe8d9-3cf9-418e-ac07-d0206cb32743 | |
dc.identifier | 85050910300 | |
dc.identifier | 000395541100005 | |
dc.identifier.citation | Sayer , L H , Florence , G J & Smith , T 2017 , ' A biocatalytic approach towards the stereoselective synthesis of protected inositols ' , Reaction Chemistry and Engineering , vol. 2 , no. 1 , pp. 44-49 . https://doi.org/10.1039/c6re00175k | en |
dc.identifier.issn | 2058-9883 | |
dc.identifier.other | ORCID: /0000-0001-9921-4399/work/56638887 | |
dc.identifier.uri | https://hdl.handle.net/10023/12320 | |
dc.description | The authors thank the EPSRC and the University of St Andrews for PhD studentship funding. | en |
dc.description.abstract | A biocatalytic flow system utilising Trypanosoma brucei L-myo-inositol 1-phosphate synthase has been developed to prepare significant quantities of L-myo-inositol 1-phosphate. Using this highly valuable biochemical, we have demonstrated its utility as a viable starting material in a drastically improved and shortened synthesis of a key intermediate in the synthesis of the biologically important myo-inositol derivatives. This biotransformation allows rapid and stereospecific inositol derivatives to be synthesized, on a larger scale than ever before. | |
dc.format.extent | 6 | |
dc.format.extent | 781994 | |
dc.language.iso | eng | |
dc.relation.ispartof | Reaction Chemistry and Engineering | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | A biocatalytic approach towards the stereoselective synthesis of protected inositols | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.identifier.doi | https://doi.org/10.1039/c6re00175k | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-12-12 | |
dc.identifier.url | http://www.rsc.org/suppdata/c6/re/c6re00175k/c6re00175k1.pdf | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.