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dc.contributor.authorSayer, Lloyd H.
dc.contributor.authorFlorence, Gordon J.
dc.contributor.authorSmith, Terry
dc.date.accessioned2017-12-13T00:32:00Z
dc.date.available2017-12-13T00:32:00Z
dc.date.issued2017-02-01
dc.identifier.citationSayer , L H , Florence , G J & Smith , T 2017 , ' A biocatalytic approach towards the stereoselective synthesis of protected inositols ' , Reaction Chemistry and Engineering , vol. 2 , no. 1 , pp. 44-49 . https://doi.org/10.1039/c6re00175ken
dc.identifier.issn2058-9883
dc.identifier.otherPURE: 248184898
dc.identifier.otherPURE UUID: a3afe8d9-3cf9-418e-ac07-d0206cb32743
dc.identifier.otherScopus: 85050910300
dc.identifier.otherORCID: /0000-0001-9921-4399/work/56638887
dc.identifier.otherWOS: 000395541100005
dc.identifier.urihttp://hdl.handle.net/10023/12320
dc.descriptionThe authors thank the EPSRC and the University of St Andrews for PhD studentship funding.en
dc.description.abstractA biocatalytic flow system utilising Trypanosoma brucei L-myo-inositol 1-phosphate synthase has been developed to prepare significant quantities of L-myo-inositol 1-phosphate. Using this highly valuable biochemical, we have demonstrated its utility as a viable starting material in a drastically improved and shortened synthesis of a key intermediate in the synthesis of the biologically important myo-inositol derivatives. This biotransformation allows rapid and stereospecific inositol derivatives to be synthesized, on a larger scale than ever before.
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofReaction Chemistry and Engineeringen
dc.rights© 2016 the Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1039/C6RE00175Ken
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleA biocatalytic approach towards the stereoselective synthesis of protected inositolsen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.identifier.doihttps://doi.org/10.1039/c6re00175k
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-12-12
dc.identifier.urlhttp://www.rsc.org/suppdata/c6/re/c6re00175k/c6re00175k1.pdfen


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