A biocatalytic approach towards the stereoselective synthesis of protected inositols
Date
01/02/2017Metadata
Show full item recordAbstract
A biocatalytic flow system utilising Trypanosoma brucei L-myo-inositol 1-phosphate synthase has been developed to prepare significant quantities of L-myo-inositol 1-phosphate. Using this highly valuable biochemical, we have demonstrated its utility as a viable starting material in a drastically improved and shortened synthesis of a key intermediate in the synthesis of the biologically important myo-inositol derivatives. This biotransformation allows rapid and stereospecific inositol derivatives to be synthesized, on a larger scale than ever before.
Citation
Sayer , L H , Florence , G J & Smith , T 2017 , ' A biocatalytic approach towards the stereoselective synthesis of protected inositols ' , Reaction Chemistry and Engineering , vol. 2 , no. 1 , pp. 44-49 . https://doi.org/10.1039/c6re00175k
Publication
Reaction Chemistry and Engineering
Status
Peer reviewed
ISSN
2058-9883Type
Journal article
Description
The authors thank the EPSRC and the University of St Andrews for PhD studentship funding.Collections
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