A biocatalytic approach towards the stereoselective synthesis of protected inositols
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A biocatalytic flow system utilising Trypanosoma brucei L-myo-inositol 1-phosphate synthase has been developed to prepare significant quantities of L-myo-inositol 1-phosphate. Using this highly valuable biochemical, we have demonstrated its utility as a viable starting material in a drastically improved and shortened synthesis of a key intermediate in the synthesis of the biologically important myo-inositol derivatives. This biotransformation allows rapid and stereospecific inositol derivatives to be synthesized, on a larger scale than ever before.
Sayer , L H , Florence , G J & Smith , T 2017 , ' A biocatalytic approach towards the stereoselective synthesis of protected inositols ' Reaction Chemistry and Engineering , vol 2 , no. 1 , pp. 44-49 . DOI: 10.1039/c6re00175k
Reaction Chemistry and Engineering
© 2016 the Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1039/C6RE00175K
The authors thank the EPSRC and the University of St Andrews for PhD studentship funding.
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