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dc.contributor.authorGoodbourn, S
dc.contributor.authorRandall, Richard Edward
dc.identifier.citationGoodbourn , S & Randall , R E 2009 , ' The regulation of type I interferon production by paramyxoviruses ' , Journal of Interferon and Cytokine Research , vol. 29 , no. 9 , pp. 539 - 547 .
dc.identifier.otherPURE: 455126
dc.identifier.otherPURE UUID: 29fa2ed8-605f-4c61-82cd-72ca82389ac2
dc.identifier.otherWOS: 000269855700008
dc.identifier.otherScopus: 70349231214
dc.identifier.otherORCID: /0000-0002-9304-6678/work/60426973
dc.descriptionResearch supported by The Wellcome Trust (087751/A/08/Z)en
dc.description.abstractExperimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha. However, in the last few years it has become clear that viruses in general mount a major challenge to the IFN system, and paramyxoviruses are no exception. Indeed, most paramyxoviruses encode mechanisms to inhibit both the production of, and response to, type I IFN. Here we review our knowledge of the type I IFN-inducing signals (by so-called pathogen-associated molecular patterns, or PAMPs) produced during paramyxovirus infections, and discuss how paramyxoviruses limit the production of PAMPs and inhibit the cellular responses to PAMPs by interfering with the activities of the pattern recognition receptors (PRRs), mda-5, and RIG-I, as well as downstream components in the type I IFN induction cascades.
dc.relation.ispartofJournal of Interferon and Cytokine Researchen
dc.rightsThis is a copy of an article accepted in the Journal of Interferon and Cytokine Research © 2009 [copyright Mary Ann Liebert, Inc.]; Journal of Interferon and Cytokine Research is available online at:
dc.subjectRespiratory syncytial virusen
dc.subjectViral-rna synthesisen
dc.subjectNonstructural c proteinen
dc.subjectInduced antiviral stateen
dc.subjectCysteine-rich domainen
dc.subjectQR355 Virologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleThe regulation of type I interferon production by paramyxovirusesen
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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