The regulation of type I interferon production by paramyxoviruses
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Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha. However, in the last few years it has become clear that viruses in general mount a major challenge to the IFN system, and paramyxoviruses are no exception. Indeed, most paramyxoviruses encode mechanisms to inhibit both the production of, and response to, type I IFN. Here we review our knowledge of the type I IFN-inducing signals (by so-called pathogen-associated molecular patterns, or PAMPs) produced during paramyxovirus infections, and discuss how paramyxoviruses limit the production of PAMPs and inhibit the cellular responses to PAMPs by interfering with the activities of the pattern recognition receptors (PRRs), mda-5, and RIG-I, as well as downstream components in the type I IFN induction cascades.
Goodbourn , S & Randall , R E 2009 , ' The regulation of type I interferon production by paramyxoviruses ' Journal of Interferon and Cytokine Research , vol 29 , no. 9 , pp. 539 - 547 . DOI: 10.1089/jir.2009.0071
Journal of Interferon and Cytokine Research
This is a copy of an article accepted in the Journal of Interferon and Cytokine Research © 2009 [copyright Mary Ann Liebert, Inc.]; Journal of Interferon and Cytokine Research is available online at: http://www.liebertonline.com.
Research supported by The Wellcome Trust (087751/A/08/Z)
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