The Cajal body and the nucleolus : “in a relationship” or “it's complicated”?
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From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the two structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.
Trinkle-Mulcahy , L & Sleeman , J E 2017 , ' The Cajal body and the nucleolus : “in a relationship” or “it's complicated”? ' RNA Biology , vol. 14 , no. 6 , pp. 739-751 . DOI: 10.1080/15476286.2016.1236169
© 2016, Taylor & Francis. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.tandfonline.com / https://dx.doi.org/10.1080/15476286.2016.1236169
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