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Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors

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Kelsey_2017_PLoSONE_FollicleStimulating_CC.pdf (409.7Kb)
Date
20/07/2017
Author
Kelsey, Thomas W.
McConville, Lauren
Edgar, Angela B.
Ungurianu, Alex I.
Mitchell, Rod T
Anderson, Richard A.
Wallace, W. Hamish B.
Keywords
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RJ Pediatrics
DAS
SDG 3 - Good Health and Well-being
Metadata
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Abstract
The accuracy of Follicle Stimulating Hormone as a predictor of azoospermia in adult survivors of childhood cancer is unclear, with conflicting results in the published literature. A systematic review and post hoc analysis of combined data (n = 367) were performed on all published studies containing extractable data on both serum Follicle Stimulating Hormone concentration and semen concentration in survivors of childhood cancer. PubMed and Medline databases were searched up to March 2017 by two blind investigators. Articles were included if they contained both serum FSH concentration and semen concentration, used World Health Organisation certified methods for semen analysis, and the study participants were all childhood cancer survivors. There was no evidence for either publication bias or heterogeneity for the five studies. For the combined data (n = 367) the optimal Follicle Stimulating Hormone threshold was 10.4 IU/L with specificity 81% (95% CI 76%–86%) and sensitivity 83% (95% CI 76%–89%). The AUC was 0.89 (95%CI 0.86–0.93). A range of threshold FSH values for the diagnosis of azoospermia with their associated sensitivities and specificities were calculated. This study provides strong supporting evidence for the use of serum Follicle Stimulating Hormone as a surrogate biomarker for azoospermia in adult males who have been treated for childhood cancer.
Citation
Kelsey , T W , McConville , L , Edgar , A B , Ungurianu , A I , Mitchell , R T , Anderson , R A & Wallace , W H B 2017 , ' Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors ' , PLoS One , vol. 12 , no. 7 , e0181377 . https://doi.org/10.1371/journal.pone.0181377
Publication
PLoS One
Status
Peer reviewed
DOI
https://doi.org/10.1371/journal.pone.0181377
ISSN
1932-6203
Type
Journal article
Rights
© 2017 Kelsey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description
Funding: RTM is supported by a Wellcome Trust Intermediate Clinical Fellowship (grant no: 098522), https://wellcome.ac.uk/what-we-do/directories/intermediate-clinical-fellowships-people-funded. TWK is supported by Engineering and Physical Sciences Research Council grant EP/P015638/1, http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/P015638/1.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/11275

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