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Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents

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Harris_Birtill_2016_MSEC_GoldNanorods_CC.pdf (1.206Mb)
Date
01/02/2016
Author
Gallina, Maria Elena
Zhou, Yu
Johnson, Christopher J
Harris-Birtill, David
Singh, Mohan
Zhao, Hailin
Ma, Daqing
Cass, Tony
Elson, Daniel S
Keywords
Aptamers
Fluorescent Dyes
Gold
HeLa Cells
Humans
Nanotubes
Neoplasms
Phototherapy
Nucleotide
QA75 Electronic computers. Computer science
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
TP Chemical technology
NDAS
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Abstract
GNRs are emerging as a new class of probes for theradiagnostic applications thanks to their unique optical properties. However, the achievement of proper nanoconstructs requires the synthesis of highly pure GNRs with well-defined aspect ratio (AR), in addition to extensive surface chemistry modification to provide them with active targeting and, possibly, multifunctionality. In this work, we refined the method of the seed mediated growth and developed a robust procedure for the fabrication of GNRs with specific AR. We also revealed and characterized unexplored aging phenomena that follow the synthesis and consistently alter GNRs' final AR. Such advances appreciably improved the feasibility of GNRs fabrication and offered useful insights on the growth mechanism. We next produced fluorescent, biocompatible, aptamer-conjugated GNRs by performing ligand exchange followed by bioconjugation to anti-cancer oligonucleotide AS1411. In vitro studies showed that our nanoconstructs selectively target cancer cells while showing negligible cytotoxicity. As a result, our aptamer-conjugated GNRs constitute ideal cancer-selective multifunctional probes and promising candidates as photothermal therapy agents.
Citation
Gallina , M E , Zhou , Y , Johnson , C J , Harris-Birtill , D , Singh , M , Zhao , H , Ma , D , Cass , T & Elson , D S 2016 , ' Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents ' , Materials Science and Engineering: B , vol. 59 , pp. 324-332 . https://doi.org/10.1016/j.msec.2015.09.101
Publication
Materials Science and Engineering: B
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.msec.2015.09.101
ISSN
0921-5107
Type
Journal article
Rights
© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Description
Funding for this project was provided by the ERC grant StG242991.
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  • University of St Andrews Research
URL
http://www.sciencedirect.com/science/article/pii/S0928493115304288#appd001
URI
http://hdl.handle.net/10023/10784

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

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