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dc.contributor.authorLi, Wen-Chang
dc.contributor.authorZhu, Xiao-Yue
dc.contributor.authorRitson, Emma
dc.date.accessioned2017-05-05T16:30:13Z
dc.date.available2017-05-05T16:30:13Z
dc.date.issued2017-04-18
dc.identifier.citationLi , W-C , Zhu , X-Y & Ritson , E 2017 , ' Mechanosensory stimulation evokes acute concussion-like behavior by activating GIRKs coupled to muscarinic receptors in a simple vertebrate ' , eNeuro , vol. 4 , no. 2 , 0073-17.2017 . https://doi.org/10.1523/ENEURO.0073-17.2017en
dc.identifier.issn2373-2822
dc.identifier.otherPURE: 249712058
dc.identifier.otherPURE UUID: afd77423-ef90-4f7a-b1a2-9834c1beda0a
dc.identifier.otherScopus: 85032159106
dc.identifier.otherWOS: 000419523100011
dc.identifier.otherORCID: /0000-0002-1179-6636/work/64361131
dc.identifier.urihttp://hdl.handle.net/10023/10713
dc.descriptionThis work was supported by BBSRC (BB/L00111X).en
dc.description.abstractMost vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behaviour in a simple vertebrate, the Xenopus Laevis tadpole. We find that concussion-like behaviour can be reliably induced by the mechanosensory stimulation of the head skin without direct physical impacts on the brain. Head skin stimulation activates a cholinergic pathway which then opens G-protein coupled inward-rectifying potassium channels (GIRKs) via postsynaptic M2 muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion. We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head.
dc.language.isoeng
dc.relation.ispartofeNeuroen
dc.rightsCopyright © 2017 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.en
dc.subjectBrainstemen
dc.subjectConcussionen
dc.subjectGIRKen
dc.subjectMechanosensoryen
dc.subjectMuscarinicen
dc.subjectSwimmingen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subjectBDCen
dc.subject.lccRC0321en
dc.titleMechanosensory stimulation evokes acute concussion-like behavior by activating GIRKs coupled to muscarinic receptors in a simple vertebrateen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1523/ENEURO.0073-17.2017
dc.description.statusPeer revieweden


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