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Mechanosensory stimulation evokes acute concussion-like behavior by activating GIRKs coupled to muscarinic receptors in a simple vertebrate

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Date
18/04/2017
Author
Li, Wen-Chang
Zhu, Xiao-Yue
Ritson, Emma
Keywords
Brainstem
Concussion
GIRK
Mechanosensory
Muscarinic
Swimming
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
NDAS
BDC
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Abstract
Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behaviour in a simple vertebrate, the Xenopus Laevis tadpole. We find that concussion-like behaviour can be reliably induced by the mechanosensory stimulation of the head skin without direct physical impacts on the brain. Head skin stimulation activates a cholinergic pathway which then opens G-protein coupled inward-rectifying potassium channels (GIRKs) via postsynaptic M2 muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion. We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head.
Citation
Li , W-C , Zhu , X-Y & Ritson , E 2017 , ' Mechanosensory stimulation evokes acute concussion-like behavior by activating GIRKs coupled to muscarinic receptors in a simple vertebrate ' , eNeuro , vol. 4 , no. 2 , 0073-17.2017 . https://doi.org/10.1523/ENEURO.0073-17.2017
Publication
eNeuro
Status
Peer reviewed
DOI
https://doi.org/10.1523/ENEURO.0073-17.2017
ISSN
2373-2822
Type
Journal article
Rights
Copyright © 2017 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Description
This work was supported by BBSRC (BB/L00111X).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/10713

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