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dc.contributor.authorAlbuixech-Crespo, Beatriz
dc.contributor.authorLópez-Blanch, Laura
dc.contributor.authorBurguera, Demian
dc.contributor.authorMaeso, Ignacio
dc.contributor.authorSánchez Arrones, Luisa
dc.contributor.authorMoreno-Bravo, Juan Antonio
dc.contributor.authorSomorjai, Ildiko
dc.contributor.authorPascual-Anaya, Juan
dc.contributor.authorPuelles, Eduardo
dc.contributor.authorBovolenta, Paola
dc.contributor.authorGarcia-Fernàndez, Jordi
dc.contributor.authorPuelles, Luis
dc.contributor.authorIrimia, Manuel
dc.contributor.authorFerran, José Luis
dc.date.accessioned2017-04-20T10:30:15Z
dc.date.available2017-04-20T10:30:15Z
dc.date.issued2017-04-19
dc.identifier249396991
dc.identifier0304eab7-5853-4324-a6b1-984583849dec
dc.identifier85019031942
dc.identifier000400423600015
dc.identifier.citationAlbuixech-Crespo , B , López-Blanch , L , Burguera , D , Maeso , I , Sánchez Arrones , L , Moreno-Bravo , J A , Somorjai , I , Pascual-Anaya , J , Puelles , E , Bovolenta , P , Garcia-Fernàndez , J , Puelles , L , Irimia , M & Ferran , J L 2017 , ' Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain ' , PLoS Biology , vol. 15 , no. 4 , e2001573 . https://doi.org/10.1371/journal.pbio.2001573en
dc.identifier.issn1544-9173
dc.identifier.otherORCID: /0000-0001-5243-6664/work/46168664
dc.identifier.urihttps://hdl.handle.net/10023/10631
dc.descriptionFunding: Marine Alliance for Science and Technology Scotland (MASTS).en
dc.description.abstractAll vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.
dc.format.extent34
dc.format.extent11162136
dc.language.isoeng
dc.relation.ispartofPLoS Biologyen
dc.subjectQH301 Biologyen
dc.subjectDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccQH301en
dc.titleMolecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brainen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.identifier.doi10.1371/journal.pbio.2001573
dc.description.statusPeer revieweden


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