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Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

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Date
19/04/2017
Author
Albuixech-Crespo, Beatriz
López-Blanch, Laura
Burguera, Demian
Maeso, Ignacio
Sánchez Arrones, Luisa
Moreno-Bravo, Juan Antonio
Somorjai, Ildiko
Pascual-Anaya, Juan
Puelles, Eduardo
Bovolenta, Paola
Garcia-Fernàndez, Jordi
Puelles, Luis
Irimia, Manuel
Ferran, José Luis
Keywords
QH301 Biology
DAS
BDC
R2C
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Abstract
All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.
Citation
Albuixech-Crespo , B , López-Blanch , L , Burguera , D , Maeso , I , Sánchez Arrones , L , Moreno-Bravo , J A , Somorjai , I , Pascual-Anaya , J , Puelles , E , Bovolenta , P , Garcia-Fernàndez , J , Puelles , L , Irimia , M & Ferran , J L 2017 , ' Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain ' , PLoS Biology , vol. 15 , no. 4 , e2001573 . https://doi.org/10.1371/journal.pbio.2001573
Publication
PLoS Biology
Status
Peer reviewed
DOI
https://doi.org/10.1371/journal.pbio.2001573
ISSN
1544-9173
Type
Journal article
Rights
© 2017 Albuixech-Crespo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description
Funding: Marine Alliance for Science and Technology Scotland (MASTS).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/10631

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