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Within host RNA virus persistence : mechanisms and consequences

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Randall_2017_COV_RNAVirus_CC.pdf (283.2Kb)
Date
04/2017
Author
Randall, Richard E.
Griffin, Diane E.
Funder
The Wellcome Trust
Grant ID
101788/Z/13/Z
Keywords
QH301 Biology
QR180 Immunology
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Abstract
In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA viruses can establish “within host” persistent infections that occasionally lead to chronic or reactivated disease. Despite the importance of “within host” persistent RNA virus infections, much has still to be learnt about the molecular mechanisms by which RNA viruses establish persistent infections, why innate and adaptive immune responses fail to rapidly clear these infections, and the epidemiological and potential disease consequences of such infections.
Citation
Randall , R E & Griffin , D E 2017 , ' Within host RNA virus persistence : mechanisms and consequences ' , Current Opinion in Virology , vol. 23 , pp. 35-42 . https://doi.org/10.1016/j.coviro.2017.03.001
Publication
Current Opinion in Virology
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.coviro.2017.03.001
ISSN
1879-6257
Type
Journal item
Rights
© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).
Description
RER is funded by the Wellcome Trust, UK (Grant 101788/Z/13/Z) and DEG by US National Institutes of Health (R01 NS038932).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/10531

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

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