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dc.contributor.authorRandall, Richard E.
dc.contributor.authorGriffin, Diane E.
dc.date.accessioned2017-03-27T14:30:11Z
dc.date.available2017-03-27T14:30:11Z
dc.date.issued2017-04
dc.identifier.citationRandall , R E & Griffin , D E 2017 , ' Within host RNA virus persistence : mechanisms and consequences ' , Current Opinion in Virology , vol. 23 , pp. 35-42 . https://doi.org/10.1016/j.coviro.2017.03.001en
dc.identifier.issn1879-6257
dc.identifier.otherPURE: 249327586
dc.identifier.otherPURE UUID: 7158944e-5826-47c3-bee1-88c23622b59d
dc.identifier.otherScopus: 85015705068
dc.identifier.otherWOS: 000404702000008
dc.identifier.urihttp://hdl.handle.net/10023/10531
dc.descriptionRER is funded by the Wellcome Trust, UK (Grant 101788/Z/13/Z) and DEG by US National Institutes of Health (R01 NS038932).en
dc.description.abstractIn a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA viruses can establish “within host” persistent infections that occasionally lead to chronic or reactivated disease. Despite the importance of “within host” persistent RNA virus infections, much has still to be learnt about the molecular mechanisms by which RNA viruses establish persistent infections, why innate and adaptive immune responses fail to rapidly clear these infections, and the epidemiological and potential disease consequences of such infections.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofCurrent Opinion in Virologyen
dc.rights© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).en
dc.subjectQH301 Biologyen
dc.subjectQR180 Immunologyen
dc.subject.lccQH301en
dc.subject.lccQR180en
dc.titleWithin host RNA virus persistence : mechanisms and consequencesen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1016/j.coviro.2017.03.001
dc.description.statusPeer revieweden


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