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The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain

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Swiatek&MacNeill-BiologyDirect5(17).pdf (1.733Mb)
Date
12/04/2010
Author
Swiatek, Agnieszka
MacNeill, Stuart Andrew
Keywords
QH301 Biology
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Abstract
Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) of archaeal primase and the B-domains of the archaeo-eukaryotic GINS proteins in the form of a conserved structural domain comprising a three-stranded antiparallel beta-sheet adjacent to an alpha-helix and a two-stranded beta-sheet or hairpin. The presence of a shared domain in archaeal PriS and GINS proteins, the genes for which are often found adjacent on the chromosome, suggests simple mechanisms for the evolution of these proteins.
Citation
Swiatek , A & MacNeill , S A 2010 , ' The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain ' , Biology Direct , vol. 5 , no. 1 , pp. 17 . https://doi.org/10.1186/1745-6150-5-17
Publication
Biology Direct
Status
Peer reviewed
DOI
https://doi.org/10.1186/1745-6150-5-17
ISSN
1745-6150
Type
Journal article
Rights
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description
This work was funded by the Scottish Universities Life Sciences Alliance (SULSA).
Collections
  • Biology Research
  • Biomedical Sciences Research Complex (BSRC) Research
  • University of St Andrews Research
URL
http://www.scopus.com/inward/record.url?scp=77950637780&partnerID=8YFLogxK
http://www.biology-direct.com/content/5/1/17
URI
http://hdl.handle.net/10023/1047

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