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The common marmoset genome provides insight into primate biology and evolution
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dc.contributor.author | The Marmoset Genome Sequencing and Analysis Consortium | |
dc.date.accessioned | 2017-02-10T17:30:08Z | |
dc.date.available | 2017-02-10T17:30:08Z | |
dc.date.issued | 2014-08 | |
dc.identifier.citation | The Marmoset Genome Sequencing and Analysis Consortium 2014 , ' The common marmoset genome provides insight into primate biology and evolution ' , Nature Genetics , vol. 46 , no. 8 , pp. 850-857 . https://doi.org/10.1038/ng.3042 | en |
dc.identifier.issn | 1061-4036 | |
dc.identifier.other | PURE: 249098708 | |
dc.identifier.other | PURE UUID: feb79a7b-a64a-4d7b-9b59-d89ffcb15294 | |
dc.identifier.other | PubMed: 25038751 | |
dc.identifier.other | PubMedCentral: PMC4138798 | |
dc.identifier.other | Scopus: 84905588751 | |
dc.identifier.uri | https://hdl.handle.net/10023/10272 | |
dc.description.abstract | We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. | |
dc.format.extent | 8 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Genetics | en |
dc.rights | © 2014 Nature America, Inc. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. | en |
dc.subject | QH426 Genetics | en |
dc.subject | QH301 Biology | en |
dc.subject.lcc | QH426 | en |
dc.subject.lcc | QH301 | en |
dc.title | The common marmoset genome provides insight into primate biology and evolution | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Centre for Biological Diversity | en |
dc.identifier.doi | https://doi.org/10.1038/ng.3042 | |
dc.description.status | Peer reviewed | en |
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