Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorThe Marmoset Genome Sequencing and Analysis Consortium
dc.date.accessioned2017-02-10T17:30:08Z
dc.date.available2017-02-10T17:30:08Z
dc.date.issued2014-08
dc.identifier.citationThe Marmoset Genome Sequencing and Analysis Consortium 2014 , ' The common marmoset genome provides insight into primate biology and evolution ' , Nature Genetics , vol. 46 , no. 8 , pp. 850-857 . https://doi.org/10.1038/ng.3042en
dc.identifier.issn1061-4036
dc.identifier.otherPURE: 249098708
dc.identifier.otherPURE UUID: feb79a7b-a64a-4d7b-9b59-d89ffcb15294
dc.identifier.otherPubMed: 25038751
dc.identifier.otherPubMedCentral: PMC4138798
dc.identifier.otherScopus: 84905588751
dc.identifier.urihttps://hdl.handle.net/10023/10272
dc.description.abstractWe report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofNature Geneticsen
dc.rights© 2014 Nature America, Inc. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.en
dc.subjectQH426 Geneticsen
dc.subjectQH301 Biologyen
dc.subject.lccQH426en
dc.subject.lccQH301en
dc.titleThe common marmoset genome provides insight into primate biology and evolutionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.identifier.doihttps://doi.org/10.1038/ng.3042
dc.description.statusPeer revieweden


This item appears in the following Collection(s)

Show simple item record