The common marmoset genome provides insight into primate biology and evolution
Date
08/2014Metadata
Show full item recordAbstract
We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application.
Citation
The Marmoset Genome Sequencing and Analysis Consortium 2014 , ' The common marmoset genome provides insight into primate biology and evolution ' , Nature Genetics , vol. 46 , no. 8 , pp. 850-857 . https://doi.org/10.1038/ng.3042
Publication
Nature Genetics
Status
Peer reviewed
DOI
10.1038/ng.3042ISSN
1061-4036Type
Journal article
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