One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase

Corr, Michael J.; Smith, Duncan R. M.; Goss, Rebecca J. M.

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dc.contributor.author	Corr, Michael J.
dc.contributor.author	Smith, Duncan R. M.
dc.contributor.author	Goss, Rebecca J. M.
dc.date.accessioned	2017-02-10T00:32:37Z
dc.date.available	2017-02-10T00:32:37Z
dc.date.issued	2016-11-17
dc.identifier	240813230
dc.identifier	d84faeb5-5b98-462f-a08a-f5f228a0689b
dc.identifier	84975745483
dc.identifier	000386861000017
dc.identifier.citation	Corr , M J , Smith , D R M & Goss , R J M 2016 , ' One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase ' , Tetrahedron , vol. 72 , no. 46 , pp. 7306-7310 . https://doi.org/10.1016/j.tet.2016.02.016	en
dc.identifier.issn	0040-4020
dc.identifier.uri	https://hdl.handle.net/10023/10265
dc.description	The authors thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779, and the University of St Andrews for a studentship (to D. R. M. Smith).	en
dc.description.abstract	We report, for the first time, the use of tryptophan synthase in the generation of L- dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.
dc.format.extent	5
dc.format.extent	532128
dc.language.iso	eng
dc.relation.ispartof	Tetrahedron	en
dc.subject	Biotransformation	en
dc.subject	Dihalotryptophan	en
dc.subject	Alkynyltryptophan	en
dc.subject	Tryptophan synthase	en
dc.subject	QD Chemistry	en
dc.subject	NDAS	en
dc.subject.lcc	QD	en
dc.title	One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase	en
dc.type	Journal article	en
dc.contributor.sponsor	European Research Council	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.contributor.institution	University of St Andrews. EaSTCHEM	en
dc.contributor.institution	University of St Andrews. Biomedical Sciences Research Complex	en
dc.identifier.doi	10.1016/j.tet.2016.02.016
dc.description.status	Peer reviewed	en
dc.date.embargoedUntil	2017-02-09
dc.identifier.url	http://www.sciencedirect.com/science/article/pii/S0040402016300795#appd001	en
dc.identifier.grantnumber	GCGXC	en

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