One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase
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We report, for the first time, the use of tryptophan synthase in the generation of L- dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.
Corr , M J , Smith , D R M & Goss , R J M 2016 , ' One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase ' Tetrahedron , vol 72 , no. 46 , pp. 7306-7310 . DOI: 10.1016/j.tet.2016.02.016
Copyright 2016 Elsevier Ltd. All rights reserved. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at http://dx.doi.org/10.1016/j.tet.2016.02.016
The authors thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779, and the University of St Andrews for a studentship (to D. R. M. Smith).
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