Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst

Querard, Pierre; Perepichka, Inna; Zysman-Colman, Eli; Li, Chao-Jun

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dc.contributor.author	Querard, Pierre
dc.contributor.author	Perepichka, Inna
dc.contributor.author	Zysman-Colman, Eli
dc.contributor.author	Li, Chao-Jun
dc.date.accessioned	2017-01-13T15:30:11Z
dc.date.available	2017-01-13T15:30:11Z
dc.date.issued	2016-12-06
dc.identifier.citation	Querard , P , Perepichka , I , Zysman-Colman , E & Li , C-J 2016 , ' Copper-catalyzed asymmetric sp 3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst ' , Beilstein Journal of Organic Chemistry , vol. 12 , pp. 2636-2643 . https://doi.org/10.3762/bjoc.12.260	en
dc.identifier.issn	1860-5397
dc.identifier.other	PURE: 248878156
dc.identifier.other	PURE UUID: 262749ae-f868-4ee1-97c8-106ba91655df
dc.identifier.other	Scopus: 85008153150
dc.identifier.other	ORCID: /0000-0001-7183-6022/work/56639095
dc.identifier.other	WOS: 000391505400002
dc.identifier.uri	https://hdl.handle.net/10023/10099
dc.description	We are grateful to the Canada Research Chair (Tier 1) foundation (to C.-J. Li), NSERC, CFI, and FQRNT (CCVC) for their support of our research.	en
dc.description.abstract	This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.
dc.format.extent	8
dc.language.iso	eng
dc.relation.ispartof	Beilstein Journal of Organic Chemistry	en
dc.rights	© 2016 Querard et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.subject	C-H arylation	en
dc.subject	Copper catalyst	en
dc.subject	Enantioselectivity	en
dc.subject	Visible light	en
dc.subject	QD Chemistry	en
dc.subject	Organic Chemistry	en
dc.subject	NDAS	en
dc.subject.lcc	QD	en
dc.title	Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst	en
dc.type	Journal article	en
dc.description.version	Publisher PDF	en
dc.contributor.institution	University of St Andrews. Organic Semiconductor Centre	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.contributor.institution	University of St Andrews. EaSTCHEM	en
dc.identifier.doi	https://doi.org/10.3762/bjoc.12.260
dc.description.status	Peer reviewed	en

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