Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst
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This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.
Querard , P , Perepichka , I , Zysman-Colman , E & Li , C-J 2016 , ' Copper-catalyzed asymmetric sp 3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst ' Beilstein Journal of Organic Chemistry , vol 12 , pp. 2636-2643 . DOI: 10.3762/bjoc.12.260
Beilstein Journal of Organic Chemistry
© 2016 Querard et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DescriptionWe are grateful to the Canada Research Chair (Tier 1) foundation (to C.-J. Li), NSERC, CFI, and FQRNT (CCVC) for their support of our research.
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