Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst
Abstract
This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.
Citation
Querard , P , Perepichka , I , Zysman-Colman , E & Li , C-J 2016 , ' Copper-catalyzed asymmetric sp 3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst ' , Beilstein Journal of Organic Chemistry , vol. 12 , pp. 2636-2643 . https://doi.org/10.3762/bjoc.12.260
Publication
Beilstein Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1860-5397Type
Journal article
Rights
© 2016 Querard et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description
We are grateful to the Canada Research Chair (Tier 1) foundation (to C.-J. Li), NSERC, CFI, and FQRNT (CCVC) for their support of our research.Collections
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