Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst
Abstract
This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.
Citation
Querard , P , Perepichka , I , Zysman-Colman , E & Li , C-J 2016 , ' Copper-catalyzed asymmetric sp 3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst ' , Beilstein Journal of Organic Chemistry , vol. 12 , pp. 2636-2643 . https://doi.org/10.3762/bjoc.12.260
Publication
Beilstein Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1860-5397Type
Journal article
Description
We are grateful to the Canada Research Chair (Tier 1) foundation (to C.-J. Li), NSERC, CFI, and FQRNT (CCVC) for their support of our research.Collections
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