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Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library

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dc.contributor.authorKosikova, Tamara
dc.contributor.authorMackenzie, Harry
dc.contributor.authorPhilp, Douglas
dc.date.accessioned2016-12-23T00:32:31Z
dc.date.available2016-12-23T00:32:31Z
dc.date.issued2016-01-26
dc.identifier234637271
dc.identifierd02795db-dc74-45bb-bdd5-04e27bd4da66
dc.identifier84958056848
dc.identifier000368924100037
dc.identifier.citationKosikova , T , Mackenzie , H & Philp , D 2016 , ' Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library ' , Chemistry - A European Journal , vol. 22 , no. 5 , pp. 1831–1839 . https://doi.org/10.1002/chem.201503740en
dc.identifier.issn0947-6539
dc.identifier.otherORCID: /0000-0002-9198-4302/work/56639256
dc.identifier.urihttps://hdl.handle.net/10023/10010
dc.descriptionThis work was supported by the award of a Postgraduate Studentship from EPSRC (EP/K503162/1) to TK.en
dc.description.abstractTwo recognition-mediated reaction processes operating through a reactive binary complex drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and strength of the recognition processes employed in the dynamic system.
dc.format.extent3415810
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.subjectCombinatorial chemistryen
dc.subjectCycloaddition reactionen
dc.subjectKineticsen
dc.subjectMolecular recognitionen
dc.subjectNMR spectroscopen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleProbing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent libraryen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1002/chem.201503740
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-12-22


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