Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library
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Two recognition-mediated reaction processes operating through a reactive binary complex drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and strength of the recognition processes employed in the dynamic system.
Kosikova , T , Mackenzie , H & Philp , D 2016 , ' Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library ' Chemistry - A European Journal , vol 22 , no. 5 , pp. 1831–1839 . DOI: 10.1002/chem.201503740
Chemistry - A European Journal
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1002/chem.201503740
DescriptionThis work was supported by the award of a Postgraduate Studentship from EPSRC (EP/K503162/1) to TK.
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