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dc.contributor.authorFerrier, David E. K.
dc.date.accessioned2016-12-05T00:32:59Z
dc.date.available2016-12-05T00:32:59Z
dc.date.issued2016-09-05
dc.identifier230737282
dc.identifier1de1d570-4307-48ae-a6c7-2a1fc1ab44e0
dc.identifier84991030737
dc.identifier000385127800002
dc.identifier.citationFerrier , D E K 2016 , ' The origin of the Hox/ParaHox genes, the Ghost Locus hypothesis and the complexity of the first animal ' , Briefings in Functional Genomics , vol. 15 , no. 5 , pp. 333-341 . https://doi.org/10.1093/bfgp/elv056en
dc.identifier.issn2041-2649
dc.identifier.urihttps://hdl.handle.net/10023/9929
dc.description.abstractA key aim in evolutionary biology is to deduce ancestral states in order to better understand the evolutionary origins of clades of interest and the diversification process(es) that have elaborated them. These ancestral deductions can hit difficulties when undetected loss events are misinterpreted as ancestral absences. With the ever-increasing amounts of animal genomic sequence data we are gaining a much clearer view of the preponderance of differential gene losses across animal lineages. This has become particularly clear with recent progress in our understanding of the origins of the Hox/ParaHox developmental control genes relative to the earliest branching lineages of the animal kingdom: the sponges (Porifera), comb jellies (Ctenophora) and placozoans (Placozoa). These reassessments of the diversity and complexity of developmental control genes in the earliest animal ancestors need to go hand-in-hand with complementary advances in comparative morphology, phylogenetics and palaeontology in order to clarify our understanding of the complexity of the last common ancestor of all animals. The field is currently undergoing a shift from the traditional consensus of a sponge-like animal ancestor from which morphological and molecular elaboration subsequently evolved, to a scenario of a more complex animal ancestor, with subsequent losses and simplifications in various lineages.
dc.format.extent9
dc.format.extent840058
dc.language.isoeng
dc.relation.ispartofBriefings in Functional Genomicsen
dc.subjectAnimal evolutionen
dc.subjectHomeobox genesen
dc.subjectAnimal phylogenyen
dc.subjectEdiacaranen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleThe origin of the Hox/ParaHox genes, the Ghost Locus hypothesis and the complexity of the first animalen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.identifier.doi10.1093/bfgp/elv056
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-12-04


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