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dc.contributor.authorPradhan, Rajesh
dc.contributor.authorBanik, Milon
dc.contributor.authorCordes, David B.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorSaha, Nitis Chandra
dc.date.accessioned2016-12-02T00:33:10Z
dc.date.available2016-12-02T00:33:10Z
dc.date.issued2016-03-01
dc.identifier.citationPradhan , R , Banik , M , Cordes , D B , Slawin , A M Z & Saha , N C 2016 , ' Synthesis, characterization, X-ray crystallography and DNA binding activities of Co(III) and Cu(II) complexes with a pyrimidine-based Schiff base ligand ' Inorganica Chimica Acta , vol. 442 , pp. 70-80 . DOI: 10.1016/j.ica.2015.11.015en
dc.identifier.issn0020-1693
dc.identifier.otherPURE: 236378597
dc.identifier.otherPURE UUID: 70804bb8-9aad-4250-bd0c-382b4e06e2d4
dc.identifier.otherRIS: urn:D74DC95ADE031D9CBB155643F3BFB94A
dc.identifier.otherWOS: 000368103600010
dc.identifier.otherScopus: 84949998842
dc.identifier.urihttp://hdl.handle.net/10023/9919
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0020169315005691en
dc.description.abstractA new pyrimidine based ‘NNO’ tridentate ligand 2,4-dihydroxyacetophenone-4,6-dimethyhydrazino pyrimidine (H2MHyP) (complex I) has been synthesized and characterized by elemental analyses, mass, IR 1H NMR spectra and X-ray crystallographic studies. The Coordination mode of the synthesized ligand has been established by solid state isolation and physico-chemical identification of Co(III) and Cu(II) complexes, [Co(HMHyP)2]Cl (complex II), [Co(HMHyP)2]Br (complex III) and [Cu(HMHyP)]NO3 (complex IV) respectively. All the reported coordination complexes are 1:1 electrolytic cationic species and the ligand behaves as a monodeprotonated ‘NNO’ tridentate one in all the complex species. IR spectral data indicate that the coordination of each of the metal centre of the complexes occurs through the pyrimidine nitrogen, azomethine nitrogen and hydroxyl oxygen atoms. X-ray crystallographic data have authenticated a CoN4O2 octahedral coordination for II and III (Triclinic (P-1) and Monoclinic (P21/n), respectively) and a CuN2O2 square planar coordination for IV (Triclinic (P-1)). All the synthesized compounds were tested for their DNA binding abilities and their mode of binding with DNA. Compounds II, III & IV show potential DNA binding activities with Salmon Testis DNA.en
dc.format.extent11en
dc.language.isoeng
dc.relation.ispartofInorganica Chimica Actaen
dc.rightsCopyright © 2015 Published by Elsevier B.V. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://dx.doi.org/10.1016/j.ica.2015.11.015en
dc.subjectPyrimidineen
dc.subjectCo(III)en
dc.subjectCu(II)en
dc.subjectCrystal structuresen
dc.subjectBinding constanten
dc.subjectSalmon Testis DNAen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleSynthesis, characterization, X-ray crystallography and DNA binding activities of Co(III) and Cu(II) complexes with a pyrimidine-based Schiff base liganden
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1016/j.ica.2015.11.015
dc.description.statusPeer revieweden
dc.date.embargoedUntil01-12-20


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