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dc.contributor.authorZarins-Tutt, Joseph Scott
dc.contributor.authorTriscari Barberi, Tania
dc.contributor.authorGao, Hong
dc.contributor.authorMearns-Spragg, Andrew
dc.contributor.authorZhang, Lixin
dc.contributor.authorNewman, David
dc.contributor.authorGoss, Rebecca Jane Miriam
dc.date.accessioned2016-10-06T23:33:36Z
dc.date.available2016-10-06T23:33:36Z
dc.date.issued2015
dc.identifier.citationZarins-Tutt , J S , Triscari Barberi , T , Gao , H , Mearns-Spragg , A , Zhang , L , Newman , D & Goss , R J M 2015 , ' Prospecting for new bacterial metabolites : a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products ' Natural Product Reports , vol. Advance article . DOI: 10.1039/C5NP00111Ken
dc.identifier.issn0265-0568
dc.identifier.otherPURE: 222316993
dc.identifier.otherPURE UUID: c4cf1e80-ab93-4f6e-810e-526bc2ee5af1
dc.identifier.otherScopus: 84952705410
dc.identifier.urihttp://hdl.handle.net/10023/9619
dc.description.abstractOver the centuries, microbial secondary metabolites have played a central role in the treatment of human diseases and have revolutionised the pharmaceutical industry. With the increasing number of sequenced microbial genomes revealing a plethora of novel biosynthetic genes, natural product drug discovery is entering an exciting second golden age. Here, we provide a concise overview as an introductory guide to the main methods employed to unlock or up-regulate these so called ‘cryptic’, ‘silent’ and ‘orphan’ gene clusters, and increase the production of the encoded natural product. With a predominant focus on bacterial natural products we will discuss the importance of the bioinformatics approach for genome mining, the use of first different and simple culturing techniques and then the application of genetic engineering to unlock the microbial treasure trove.en
dc.language.isoeng
dc.relation.ispartofNatural Product Reportsen
dc.rightsCopyright 2015 the Authors. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1039/C5NP00111Ken
dc.subjectQD Chemistryen
dc.subjectT-NDASen
dc.subject.lccQDen
dc.titleProspecting for new bacterial metabolites : a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural productsen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1039/C5NP00111K
dc.description.statusPeer revieweden
dc.date.embargoedUntil06-10-20


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