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Prospecting for new bacterial metabolites : a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products
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dc.contributor.author | Zarins-Tutt, Joseph Scott | |
dc.contributor.author | Triscari Barberi, Tania | |
dc.contributor.author | Gao, Hong | |
dc.contributor.author | Mearns-Spragg, Andrew | |
dc.contributor.author | Zhang, Lixin | |
dc.contributor.author | Newman, David | |
dc.contributor.author | Goss, Rebecca Jane Miriam | |
dc.date.accessioned | 2016-10-06T23:33:36Z | |
dc.date.available | 2016-10-06T23:33:36Z | |
dc.date.issued | 2015 | |
dc.identifier | 222316993 | |
dc.identifier | c4cf1e80-ab93-4f6e-810e-526bc2ee5af1 | |
dc.identifier | 84952705410 | |
dc.identifier | 000368755100003 | |
dc.identifier.citation | Zarins-Tutt , J S , Triscari Barberi , T , Gao , H , Mearns-Spragg , A , Zhang , L , Newman , D & Goss , R J M 2015 , ' Prospecting for new bacterial metabolites : a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products ' , Natural Product Reports , vol. Advance article . https://doi.org/10.1039/C5NP00111K | en |
dc.identifier.issn | 0265-0568 | |
dc.identifier.uri | https://hdl.handle.net/10023/9619 | |
dc.description.abstract | Over the centuries, microbial secondary metabolites have played a central role in the treatment of human diseases and have revolutionised the pharmaceutical industry. With the increasing number of sequenced microbial genomes revealing a plethora of novel biosynthetic genes, natural product drug discovery is entering an exciting second golden age. Here, we provide a concise overview as an introductory guide to the main methods employed to unlock or up-regulate these so called ‘cryptic’, ‘silent’ and ‘orphan’ gene clusters, and increase the production of the encoded natural product. With a predominant focus on bacterial natural products we will discuss the importance of the bioinformatics approach for genome mining, the use of first different and simple culturing techniques and then the application of genetic engineering to unlock the microbial treasure trove. | |
dc.format.extent | 1388091 | |
dc.language.iso | eng | |
dc.relation.ispartof | Natural Product Reports | en |
dc.subject | QD Chemistry | en |
dc.subject | T-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QD | en |
dc.title | Prospecting for new bacterial metabolites : a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1039/C5NP00111K | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2016-10-06 |
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