Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.

Citation

Trose , M , Lazreg , F , Lesieur , M & Cazin , C S J 2015 , ' Copper N -heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols ' , The Journal of Organic Chemistry , vol. Article ASAP . https://doi.org/10.1021/acs.joc.5b01382

Publication

The Journal of Organic Chemistry

Status

Peer reviewed

DOI

https://doi.org/10.1021/acs.joc.5b01382

ISSN

0022-3263

Type

Journal article

Rights

© 2015 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.joc.5b01382

Description

The authors gratefully acknowledge the Royal Society (University research Fellowship to C.S.J.C) for funding.