Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols
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The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.
Trose , M , Lazreg , F , Lesieur , M & Cazin , C S J 2015 , ' Copper N -heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols ' Journal of Organic Chemistry , vol Article ASAP . DOI: 10.1021/acs.joc.5b01382
Journal of Organic Chemistry
© 2015 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.joc.5b01382
The authors gratefully acknowledge the Royal Society (University research Fellowship to C.S.J.C) for funding.
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