Simple direct formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in biosensing
MetadataShow full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
The formation of organic films on gold employing N-heterocyclic carbenes (NHCs) has been previously shown to be a useful strategy for generating stable organic films. However, NHCs or NHC precursors typically require inert atmosphere and harsh conditions for their generation and use. Herein we describe the use of benzimidazolium hydrogen carbonates as bench stable solid precursors for the preparation of NHC films in solution or by vapour-phase deposition from the solid state. The ability to prepare these films by vapour-phase deposition permitted the analysis of the films by a variety of surface science techniques, resulting in the first measurement of NHC desorption energy (158±10 kJ mol−1) and confirmation that the NHC sits upright on the surface. The use of these films in surface plasmon resonance-type biosensing is described, where they provide specific advantages versus traditional thiol-based films.
Crudden , C , Horton , H , Narouz , M , Li , Z , Smith , C , Munro , K , Baddeley , C J , Larrea , C R , Drevniok , B , Thanabalasingam , B , Maclean , A , Zenkina , O , Ebralidze , I , She , Z , Kraatz , H-B , Mosey , N , Saunders , L & Yagi , A 2016 , ' Simple direct formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in biosensing ' , Nature Communications , vol. 7 , 12654 . https://doi.org/10.1038/ncomms12654
Copyright 2016 the Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
DescriptionCRL acknowledges the Engineering and Physical Sciences Research Council (UK) for the funding of his PhD studentship (EP/M506631).
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.