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dc.contributor.authorSmith, Val
dc.contributor.authorDyrynda, Elisabeth
dc.date.accessioned2016-08-29T23:32:33Z
dc.date.available2016-08-29T23:32:33Z
dc.date.issued2015
dc.identifier.citationSmith , V & Dyrynda , E 2015 , ' Antimicrobial proteins : from old proteins, new tricks ' , Molecular Immunology , vol. 68 , no. Issue 2, Part B , pp. 383-398 . https://doi.org/10.1016/j.molimm.2015.08.009en
dc.identifier.issn0161-5890
dc.identifier.otherPURE: 204599369
dc.identifier.otherPURE UUID: 4c76e5ee-7c75-456f-be5b-41a7103980da
dc.identifier.otherScopus: 84947032980
dc.identifier.otherWOS: 000366767900001
dc.identifier.urihttp://hdl.handle.net/10023/9396
dc.description.abstractThis review describes the main types of antimicrobial peptides (AMPs) synthesised by crustaceans, primarily those identified in shrimp, crayfish, crab and lobster. It includes an overview of their range of microbicidal activities and the current landscape of our understanding of their gene expression patterns in different body tissues. It further summarises how their expression might change following various types of immune challenges. Included in the review are proteins or protein fragments that have antimicrobial properties but are more usually associated with other biological functions, or are derived from such proteins. It discusses how these unconventional AMPs might be generated at, or delivered to, sites of infection and how they might contribute to crustacean host defence in vivo. It also highlights recent work that is starting to reveal the extent of multi-functionality displayed by some decapod AMPs, particularly their participation in other aspects of host protection. Examples of such activities include proteinase inhibition, phagocytosis, antiviral activity and haematopoiesis.
dc.language.isoeng
dc.relation.ispartofMolecular Immunologyen
dc.rights© 2015. Elsevier Ltd. All rights reserved. This is the author’s version of a work that was accepted for publication in Molecular Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular Immunology, 29/08/2015, http://dx.doi.org/10.1016/j.molimm.2015.08.009en
dc.subjectAntibacterialsen
dc.subjectPenaeidinsen
dc.subjectCrustinsen
dc.subjectAnti-lipopolysaccharide factorsen
dc.subjectLyzosymeen
dc.subjectHistonesen
dc.subjectShrimpen
dc.subjectCrabsen
dc.subjectCrayfishen
dc.subjectPhagocytosisen
dc.subjectETosisen
dc.subjectHaemotapoiesisen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleAntimicrobial proteins : from old proteins, new tricksen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.identifier.doihttps://doi.org/10.1016/j.molimm.2015.08.009
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-08-29


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